Results 201 to 210 of about 2,296,637 (249)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

High Users of Primary Care Secure Messaging in the Veterans Health Administration. [PDF]

Ann Fam Med
Staloff J, Gunnink E, Rojas J, Wong ES, Hagan S, Nelson K, Reddy A.   +6 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Health professions trainee experiences transitioning to a new Federal Electronic Health Record: applying learning health system principles to support change management in the Veterans Health Administration. [PDF]

JAMIA Open
Ahlness EA, Rucci J, Matteau E, Walton E, Rinne ST.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Shifting bisphosphonate prescribing patterns for fracture prevention: a 24-year national surveillance of men in the U.S. Veterans Health Administration. [PDF]

Arch Osteoporos
Elam RE, Lo JC, Schousboe JT, Adler RA, Fink HA, Ott SM, Barzilay J, Weaver FM, Budde E, Huo Z, Jacob R, Carbone LD.   +11 more
europepmc   +1 more source

Trends in unintentional injury death among post-9/11 Army Veterans who do and do not use Veteran Health Administration services. [PDF]

Inj Epidemiol
Adams RS, Forster JE, Hoffmire CA, Gradus JL, Hostetter TA, Larson MJ, Schneider AL, Smith AA, Walsh CG, Brenner LA.   +9 more
europepmc   +1 more source

Does the Veterans Health Administration Purchase High-Quality Home Health Care? [PDF]

J Am Med Dir Assoc
Kennedy KA, DeVone F, Cornell PY, Gozalo P, Thomas KS, Gravenstein S, Magid KH, Mroz T, Jones CD.   +8 more
europepmc   +1 more source

Development and Validation of Case-Finding Algorithms to Identify Periprosthetic Joint Infections After Total Hip Arthroplasty in Veterans Health Administration Data. [PDF]

Pharmacoepidemiol Drug Saf
O'Neil JC, Pei Y, Newcomb C, Silibovsky R, O'Donnell JA, Nelson CL, Hsieh E, King J, Crystal S, Hanberg JS, Lo Re V, Weinstein EJ.   +11 more
europepmc   +1 more source