Results 161 to 170 of about 201,168 (322)

CYP2C19 Polymorphisms and Clinical Outcomes Following Percutaneous Coronary Intervention in the Million Veteran Program

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 loss‐of‐function (LOF) alleles decrease the antiplatelet effect of clopidogrel following percutaneous coronary intervention (PCI) in patients presenting with acute coronary syndrome (ACS). The impact of genotype in patients undergoing PCI for stable ischemic heart disease (SIHD) in real‐world populations is less clear.
Catherine Chanfreau‐Coffinier   +20 more
wiley   +1 more source

eBEfree: Combining Psychoeducation, Mindfulness, and Self‐Compassion in an App‐Based Psychological Intervention to Manage Binge‐Eating Symptoms: A Randomized Controlled Trial

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To develop and test the effectiveness of the eBEfree program, a 12‐session app‐based version of a previously tested psychological intervention (BEfree) that combines psycho‐education, self‐compassion, mindfulness, and Acceptance and Commitment Therapy to reduce binge‐eating symptoms.
Hugo Senra   +11 more
wiley   +1 more source

Artificial Intelligence‐Driven Innovations in Hydrogen Storage Technology

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This review presents a comprehensive overview of recent advancements in hydrogen storage technology, with a particular focus on the integration of high‐throughput screening and machine learning. It primarily covers solid‐state hydrogen storage materials, including metal hydrides, alloys, carbon‐based materials, metal‐organic frameworks, and zeolites ...
Yusong Ding   +4 more
wiley   +1 more source

eGFR slope as predictor of mortality in heart failure patients

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1217-1226, April 2025.
Abstract Aims Heart failure (HF) leads to an imbalance between heart and kidney function, resulting in poor outcomes. However, the prognostic significance of the estimated glomerular filtration rate (eGFR) trajectory in HF patients remains unclear. We analysed electronic health records (EHRs) of real‐world HF patients, assessing eGFR trajectories and ...
Sofie Verstreken   +10 more
wiley   +1 more source

Atrial fibrillation development in the heart failure population from nationwide British linked electronic health records

open access: yesESC Heart Failure, EarlyView.
Abstract Aims Atrial fibrillation (AF) is a frequent comorbidity in heart failure (HF). We analysed factors associated with new‐onset atrial fibrillation in patients with heart failure using linked real‐world UK data from primary and secondary care, along with findings from genome‐wide association studies. Methods and results Among 163 174 participants
Hiroyuki Yoshimura   +6 more
wiley   +1 more source

Ferric carboxymaltose assessment of morbidity and mortality in patients with iron deficiency and chronic heart failure (FAIR‐HF2‐DZHK05) trial: Baseline characteristics and comparison to other relevant clinical trials

open access: yesEuropean Journal of Heart Failure, EarlyView.
Differences in baseline characteristics between major trials of intravenous (IV) iron therapy in heart failure. LVEF, left ventricular ejection fraction; SGLT2, sodium–glucose cotransporter 2. Aims Prior randomized trials have reported conflicting evidence regarding the efficacy of intravenous (IV) iron in patients with heart failure with reduced ...
Stefan D. Anker   +44 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

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