Results 191 to 200 of about 1,602,703 (297)

Measurement of clinical delay intervals among younger adults with colorectal cancer using health administrative data: a population-based analysis. [PDF]

BMJ Open Gastroenterol, 2022
Castelo M, Paszat L, Hansen BE, Scheer AS, Faught N, Nguyen L, Baxter NN.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Identification of Mood Disorders in Self-Reported Versus Health Administrative Data. [PDF]

Brain Behav
Dohouin I, Laberge M, Lacasse A, Poder TG, TorSaDE Cohort working group.   +4 more
europepmc   +1 more source

Virtual family physician care during COVID-19: a mixed methods study using health administrative data and qualitative interviews. [PDF]

BMC Prim Care, 2022
Ryan BL, Brown JB, Freeman TR, Richard L, Stewart M, Meredith L, Choi YH, He JW, Cejic S, Thompson K, Reichert S, Shariff SZ, Booth R, Terry AL, Mathews M.   +14 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Investigating use of diagnostic codes for post-COVID- 19 condition in Ontario health administrative data. [PDF]

BMC Health Serv Res
Munn JS, Atzema CL, Austin PC, Butler SJ, Fidler L, Wang X, Gershon AS.   +6 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Cross-Sectional Descriptive Study Using Health Administrative Data to Examine the Characteristics of Older Adults Incurring Delayed Discharge Days for Non-Clinical Reasons During the COVID-19 Pandemic in Alberta, Canada. [PDF]

Can Geriatr J
Chan J, Gruneir A.
europepmc   +1 more source

Minimizing misclassification bias with a model to identify acetabular fractures using health administrative data: A cohort study. [PDF]

Medicine (Baltimore), 2021
Adamczyk A, Grammatopoulos G, van Walraven C.   +2 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source