Results 201 to 210 of about 1,602,703 (297)

Trends in infection-related and infection-unrelated cancer incidence among people with and without HIV infection in Ontario, Canada, 1996-2020: a population-based matched cohort study using health administrative data. [PDF]

CMAJ Open, 2023
Nicolau IA, Moineddin R, Antoniou T, Brooks JD, Gillis JL, Kendall CE, Cooper C, Cotterchio M, Salters K, Smieja M, Kroch AE, Lindsay JD, Price C, Mohamed A, Burchell AN.   +14 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Reporting a regular medical doctor index: A new measure of patient-physician affiliation for health administrative data. [PDF]

PLoS One
King C, Lavergne MR, McGrail K, Strumpf EC, Quebec-British Columbia Patient Enrolment Project Team.   +4 more
europepmc   +1 more source

Association of obstructive sleep apnea and opioids use on adverse health outcomes: A population study of health administrative data. [PDF]

PLoS One, 2022
Kendzerska T, Gomes T, Malhotra A, Gershon AS, Povitz M, McIsaac DI, Aaron SD, Chung F, Bryson GL, Talarico R, Ahmed T, Godbout M, Tanuseputro P.   +12 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Combined impact of the COVID-19 pandemic and the number of comorbidities on community antibiotic utilisation rates: a population-based retrospective cohort study using linked health administrative data in Quebec, Canada. [PDF]

BMJ Open
Fortin P, Fortin É, Sirois C, Quach C, Simard M, Magali-Ufitinema N, Sauvageau C.   +6 more
europepmc   +1 more source

Utilization of Immunotherapy in Patients with Cancer Treated in Routine Care Settings: A Population-Based Study Using Health Administrative Data. [PDF]

Oncologist, 2022
Raphael J, Richard L, Lam M, Blanchette PS, Leighl NB, Rodrigues G, Trudeau ME, Krzyzanowska MK.   +7 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Associations between patient characteristics and delayed acute care discharge post-hip fracture surgery: a cohort study using linked health administrative data in Ontario, Canada. [PDF]

BMC Musculoskelet Disord
Backman C, Li W, Shah S, Papp S, Fung SG, Dumicho AY, Tuna M, Engel FD, Webber C, Turcotte L, McIsaac DI, Beaulé PE, French-Merkley V, Poitras S, Lafleur B, Watt J, Vincent C, Straus S, Tran A, Pitzul K, Guilcher SJT, Senthinathan A, Tanuseputro P.   +22 more
europepmc   +1 more source

Residential Area Socioeconomic Deprivation is Associated with Physical Dependency and Polypharmacy in Community-Dwelling Older Adults: An Analysis of Health Administrative Data in Ireland. [PDF]

J Multidiscip Healthc, 2022
Swan L, Horgan NF, Fan CW, Warters A, O'Sullivan M.   +4 more
europepmc   +1 more source