Results 181 to 190 of about 2,016,189 (297)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Social determinants of health influence maternal health behaviors and engagement in an obesity prevention intervention. [PDF]

Transl Behav Med
Gilbert A, Martinez A, Farabi S, Cortez A, Baumann AA, Haire-Joshu D, Brownson RC, Morshed AB, Tabak RG.   +8 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Adverse Childhood Experiences, Disability and Health-Risk Behaviors [PDF]

, 2013
Schussler-Fiorenza Rose, Sophia Miryam, MD, PhD
core   +1 more source

Health Behavior [PDF]

American Journal of Public Health and the Nations Health, 1928
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Oral health behaviors and associated factors in older adults: a cross-sectional study. [PDF]

Front Oral Health
Caetano-Santos I, Canales GT, Proença L, Polido M, Mendes JJ, Canhão H, Manso AC.   +6 more
europepmc   +1 more source

Prevalence and Perception of risky health behaviors among construction workers [PDF]

, 2017
Arezes, Arias, Armour, Arndt, Barbeau, Barbeau, Barnes, Boal, Brewer, Carter, Claessen, Coups, Dement, Dong, Dong, Dutra, Evanoff, Fan, Field, Graber, Gu, Gu, Hakes, Hallowell, Ham, Heatherton, Hecht, Hjermann, Kaskutas, Knutsson, Lee, Lipscomb, Luckhaupt, Nigg, Okechukwu, Reinau, Robinson, Rodriguez-Garzon, Smith   +38 more
core   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source