Results 181 to 190 of about 2,096,055 (310)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Feasibility and Acceptability of an Incentive-Based Intervention for Health Behaviour Change Among Rural Residents in China: A Mixed-Methods Evaluation. [PDF]

Health Expect
Yan B, He Z, Zhang R, Shao B, Zheng S, Wang X, Zhou X.   +6 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Socioeconomic status and long-term health behaviour maintenance after non-communicable disease diagnosis: a multicohort study. [PDF]

BMC Med
Wang S, Zhang Y, Zhou Y, Kivimäki M, Xu X.   +4 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Proactive health behaviour intervention strategies for older T2DM patients with multimorbidity: protocol for a cluster randomised controlled trial with hybrid type 2 effectiveness-implementation design. [PDF]

BMC Prim Care
Li Y, Huang Q, Ge J, Liu Y, Geng S, Li Q, Chen X, Zhu Y, Guo X, Lu F, Xu N, Yu M, Zheng L, Jiang H.   +13 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Evaluating the impact of communicating high polygenic risk for coronary artery disease on the health behaviour of young overweight adults: a pragmatic randomised controlled trial. [PDF]

Sci Rep
Põld A, Toompere K, Elken A, Viigimaa M, Irs A, Nohrin LC, Fischer K, Milani L, Alavere H, Alloja J, Pärna K, Traks T, Kalda R, Widen E, Ripatti S, Jürisson M.   +15 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

What's the 'Secret Sauce'?: A Systematic Review of the Characteristics of Effective Digital Health Behaviour Change Interventions for Children and Adolescents. [PDF]

Health Promot J Austr
Krishna K, Portsmouth L, Harris C, Ciccarelli M.   +3 more
europepmc   +1 more source