Results 111 to 120 of about 18,630,386 (270)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A strategic analysis of health behaviour change initiatives in Africa. [PDF]

Glob Health Action, 2023
Mogo ERI, Shanawaz S, Ademola-Popoola O, Iqbal N, Aghedo O, Ademola M, Onyemaobi N, Eniayewun A, Ademusire B, Adaramola T, Ugwu A, Obi A, Lerno A, Nwagbara J, Uwimana A, Gbadamosi E, Adebisi A, Sako B.   +17 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Health and hygiene behaviour change: bottom-up meets top-down in Tibet

, 2009
The Tibet Poverty Alleviation Fund (TPAF) has been working in the Tibet Autonomous Region of the People's Republic of China since 1998 to increase the income and assets of rural Tibetans.
Wangdui, Puchung, Yeshi, Choeden, Holcombe, Susan   +2 more
core   +1 more source

Referral to and Engagement with Pulmonary Rehabilitation: A Review and Strategic Behavioural Analysis of Factors Influencing Behaviour and Intervention Opportunities

International Journal of COPD
Amanda P Moore,1 Isolt Reardon,1 Osanna Ramkissoon,1 Frances Early,2 Estelle Payerne,3 Polly-Anna Ashford,3 Stephen Holmes,4 Michael P Kelly,5 Sally J Singh,6 GM Monsur Habib,7 Jonathan Fuld,8 Fabiana Lorencatto1 On behalf of the UPTURN Team1Centre for ...
Moore AP, Reardon I, Ramkissoon O, Early F, Payerne E, Ashford PA, Holmes S, Kelly MP, Singh SJ, Habib GM, Fuld J, Lorencatto F   +11 more
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Cyber security in the workplace: Understanding and promoting behaviour change [PDF]

, 2013
Cyber security and the role employees play in securing information are major concerns for businesses. The aim of this research is to explore employee security behaviours and design interventions that can motivate behaviour change.
Blythe, John
core  

Digital health behaviour change interventions in severe mental illness: a systematic review. [PDF]

Psychol Med, 2023
Sawyer C, McKeon G, Hassan L, Onyweaka H, Martinez Agulleiro L, Guinart D, Torous J, Firth J.   +7 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source