Results 151 to 160 of about 8,126,628 (341)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Health care commissioning: the UK health policy reforms [PDF]

open access: yes, 2013
Puthussery, Shuby   +2 more
core   +1 more source

The effect of an intervention for organizing primary mental health care in Brazil: a study based on routine process indicators

open access: yesBMC Primary Care
Background The “Mental Health Care in Primary Health Care (PHC)” project (SMAPS, from Portuguese) was developed in six health regions from three Brazilian states.
Ilana Eshriqui   +12 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Construction and optimization of health behavior prediction model for the elderly in smart elderly care [PDF]

open access: yesarXiv
With the intensification of global aging, health management of the elderly has become a focus of social attention. This study designs and implements a smart elderly care service model to address issues such as data diversity, health status complexity, long-term dependence and data loss, sudden changes in behavior, and data privacy in the prediction of ...
arxiv  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

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