Results 151 to 160 of about 5,137,646 (317)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Advocate Health Care Annual Report, 1998

open access: yes
Advocate Health Care, Oak Brook, IL: Annual report for Advocate Health Care titled Measuring for Improvement . Includes data, statistics, and development plans for 8 legacy hospitals and out-patient centers.
Advocate Health - Midwest
core  

Frameworks for Health Care Quality and Disparities in Health Care Quality: A Scoping Review. [PDF]

open access: yesJ Healthc Qual
Zhang D   +15 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Annual Report, Aurora Health Care, 2009

open access: yes
Aurora Health Care, Milwaukee WI: Annual report for Aurora Health Care for the year 2009. Includes data, statistics, and general information about programs and initiatives.https://institutionalrepository.aah.org/alldocuments/1895/thumbnail ...
Advocate Health - Midwest
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Annual Report, Aurora Health Care, 2011

open access: yes
Aurora Health Care, Milwaukee WI: Annual report for Aurora Health Care for the year 2011. Includes data, statistics, and general information about programs and initiatives.https://institutionalrepository.aah.org/alldocuments/1897/thumbnail ...
Advocate Health - Midwest
core  

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