Results 51 to 60 of about 1,354,273 (314)

Uncovering nonlinear patterns in time-sensitive prehospital breathing emergencies: an exploratory machine learning study

BMC Medical Informatics and Decision Making
Background Timely prehospital care is crucial for patients presenting with high-risk time-sensitive (HRTS) conditions. However, the interplay between response time and demographic factors in patients with breathing problems remains insufficiently ...
Peter Hill, Daniel Jonsson, Jakob Lederman, Peter Bolin, Veronica Vicente   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Exploring the association of social determinants of health and clinical quality measures and performance in HRSA-funded health centres

Family Medicine and Community Health, 2021
Objective This paper explores the impact of service area-level social deprivation on health centre clinical quality measures.Design Cross-sectional data analysis of Health Resources and Services Administration (HRSA)-funded health centres.
Michael Topmiller, Jessica McCann, Jennifer Rankin, Hank Hoang, Joshua Bolton, Alek Sripipatana   +5 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Work hours and turnover intention among hospital physicians in Taiwan: does income matter?

BMC Health Services Research, 2016
Background Physician shortage has become an urgent and critical challenge to many countries. According to the workforce dynamic model, long work hours may be one major pressure point to the attrition of physicians. Financial incentive is a common tool to
Yu-Hsuan Tsai, Nicole Huang, Li-Yin Chien, Jen-Huai Chiang, Shu-Ti Chiou   +4 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Patients and health care professionals: Partners in health care in Croatia? [PDF]

, 2013
Objectives. To explore quality in hospitals from the patients’ and health care professionals’ perspective in line with Act on the Protection of Patient Rights. Design.
Montgomery Anthony, Brborovic Hana, Mustajbegovic Jadranka, Milosevic Milan   +3 more
core   +1 more source

Evaluating the implementation of the ‘Patient Safety Caravan’ for patient engagement in Riyadh, Saudi Arabia

BMC Health Services Research
Background The “Patient Safety Caravan” is a patient safety promotion campaign launched by the Saudi Patient Safety Center and adopted by Riyadh Second Health Cluster hospitals to promote a culture of patient safety.
Reem AlKhalil, Faisal Aldalbahi, Amal Al-Wathnani, Mecciya Majrashi, Turki Alshabib, Isamme AlFayyad   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source