Results 41 to 50 of about 692,418 (214)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Long-term medical and productivity costs of severe trauma: Results from a prospective cohort study.

PLoS ONE, 2021
BackgroundThrough improvements in trauma care there has been a decline in injury mortality, as more people survive severe trauma. Patients who survive severe trauma are at risk of long-term disabilities which may place a high economic burden on society ...
Marjolein van der Vlegel, Juanita A Haagsma, Roos J M Havermans, Leonie de Munter, Mariska A C de Jongh, Suzanne Polinder   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Lifetime Health Care Costs of the Danish Population

Journal of Health Economics and Outcomes Research, 2013
# Objectives Lifetime health care cost is a statistical indicator for expected health care use during the remaining lifetime of an individual. The objective of this study was to estimate the lifetime health care costs for individual gender and age strata.
Jan Sørensen, Rikke Søgaard
doaj  

Hospital care direct costs due to ambulatory care sensitive conditions related to diabetes mellitus in the Mexican public healthcare system

BMC Health Services Research
Background Hospitalizations for ambulatory care sensitive conditions (ACSC) incur substantial costs on the health system that could be partially avoided with adequate outpatient care. Complications of chronic diseases, such as diabetes mellitus (DM), are
Pedro Saturno-Hernández, Estephania Moreno-Zegbe, Ofelia Poblano-Verastegui, Laura del Pilar Torres-Arreola, Arturo C. Bautista-Morales, Cynthya Maya-Hernández, Juan David Uscanga-Castillo, Sergio Flores-Hernández, Patricia María Gómez-Cortez, Waldo Iván Vieyra-Romero   +9 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Evidence for marked underutilization of insurance billing in malignant pleural mesothelioma in Finland

Thoracic Cancer, 2021
Background Substantial variation in health care costs for malignant pleural mesothelioma (MPM) has previously been identified. Materials and Methods We analyzed the changes in health care costs in MPM in Finland during 2002–2012.
Paulus Torkki, Juuso Paajanen, Ville Kytö, Sanna Laaksonen, Jari Räsänen, Marjukka Myllärniemi, Ilkka Ilonen   +6 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Health care during electricity failure: The hidden costs.

PLoS ONE, 2020
BackgroundSurgery risks increase when electricity is accessible but unreliable. During unreliable electricity events and without data on increased risk to patients, medical professionals base their decisions on anecdotal experience.
Abigail Mechtenberg, Brady McLaughlin, Michael DiGaetano, Abigail Awodele, Leslie Omeeboh, Emmanuel Etwalu, Lydia Nanjula, Moses Musaazi, Mark Shrime   +8 more
doaj   +1 more source

Total health insurance costs in children with a migraine diagnosis compared to a control group

The Journal of Headache and Pain, 2021
Background Health care costs of migraine constitute a major issue in health economics. Several publications analyzed health care costs for adult migraine patients, based on questionnaires or secondary (health insurance) data.
Viola Obermeier, Monika Murawski, Florian Heinen, Mirjam N. Landgraf, Andreas Straube, Rüdiger von Kries, Ruth Ruscheweyh   +6 more
doaj   +1 more source