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The organisation and delivery of health improvement in general practice and primary care: a scoping study [PDF]
, 2015 Background
This project examines the organisation and delivery of health improvement activities by and within general practice and the primary health-care team. The project was designed to examine who delivers these interventions, where they are located,, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Abbott, Abbott, Abbott, Abbott, Abbott, Abbott, Abdullahi, Acheson, Adab, Adams, Agomo, Alshamsan, Amato, Anderson, Anderson, Anderson, Anderson, Anderson, Anokye, Anokye, Arksey, Ashenden, Austoker, Aveyard, Baggott, Baggott, Baker, Balkau, Bane, Banks, Baraitser, Baric, Barlow, Barnett-Page, Barnum, Barr, Barter-Godfrey, Bauld, Bauld, Baumann, Begh, Bell, Bertholet, Blenkinsopp, Boehler, Boland, Bond, Bond, Boyce, Boyd, Brabin, Brankin, Brotons, Brown, Bryan, Bryans, Bryar, Buckley, Buffels, Bunn, Burrows, Cahill, Calvert, Campbell, Campbell, Campbell, Campbell, Campbell, Cardona-Morrell, Carlisle, Carlisle, Chapple, Chauhan, Checkland, Checkland, Chew-Graham, Chiu, Chiu, Cioffe, Clamp, Clark, Cleland, Cockman, Coleman, Coleman, Coleman, Coleman, Coleman, Coleman, Coleman, Coleman, Connell, Connolly, Copello, Coulter, Coulter, Craigie, Crilly, Cupples, Cupples, Dabrera, Dachsel, Dalton, Damery, Damery, Davey, Daykin, de Lusignan, De Maeseneer, Dickinson, Dixon, Dixon-Woods, Dixon-Woods, Donyai, Doran, Doran, Dowell, Drennan, Drennan, Duaso, Dugdill, Dunkley, D’Souza, Ebrahim, Eilbert, Elley, Ellins, Emmett, Emond, Epstein, Fagan, Feder, Felce, Fisher, Fitzpatrick, Fleetcroft, Fleming, Flodgren, Freeman, Frenk, Froon, Getz, Gibbons, Gilbert, Gill, Gillam, Gillam, Gillam, Gillam, Gillespie, Goldsmith, Goodwin, Goodwin, Gordon, Goyder, Graffy, Graffy, Graham, Gravelle, Gray, Greasley, Greaves, Griffin, Griffiths, Griffiths, Grossman, Guassora, Hall, Hall, Hankey, Hanney, Harari, Harding, Harding, Harris, Hart, Herbert, Hewitson, Hillsdon, Hillsdon, Hippisley-Cox, Hoddinott, Hoddinott, Hogan, Hogg, Holden, Holt, Hooper, Horgan, Hoskins, Howse, Hughes, Hunter, Ibbotson, Jackson, Jackson, Janssen, Jenkins, Jinks, Joshi, Joyce, Kai, Kane, Kaner, Kaner, Kaner, Kaner, Kendrick, Kendrick, Kennedy, Kennedy, Kharicha, Khunti, Kirkcaldy, Knussen, Koopman, Krass, Kringos, Krogsbøll, Krumholz, Kumar, Kumar, Kyaw, Lai, Lamb, Lambert, Lamden, Lancaster, Langham, Langham, Lavin, Lawal, Lawlor, Lawlor, Laws, Laws, Lawton, Le Grand, Leavell, Leavell, Lennox, Lewis, Li, Lindsay, Little, Lloyd, Logan, Lowe, Lowther, Ma, MacAuley, Macdonald, Macpherson, Magee, Mant, Marcus, Marks, Marks, Marmot, Marshall, Marteau, Martin, Martin-Misener, Maryon-Davis, Mason, Mathews, Maynard, Mays, McAlister, McCaig, McCluskey, McCormick, McDonald, McDonald, McDonald, McDonald, McEwen, McEwen, McEwen, McEwen, McIlfatrick, McInnes, McKenna, McLean, McNaughton, McNulty, McNulty, McRobbie, Miller, Millett, Millett, Milne, Mold, Moon, Morgan, Morris, Muir, Munro, Murray, Murray, Murray, Nicholas, Nield, Nissen, Norbury, Norris, Ogden, Ogden, Okereke, Orozco, O’Donnell, O’Neill, Parry, Patel, Patel, Pavey, Peckham, Peckham, Peckham, Peckham, Peckham, Peckham, Peckham, Peckham, Peckham, Perkins, Peto, Pieterse, Pilnick, Pilnick, Pimenta, Plochg, Pomerleau, Pope, Pratt, Price, Pritchard, Prost, Raftery, Rapley, Raw, Reilly, Rennard, Rice, Rice, Richards, Ritchie, Robertson, Robson, Robson, Romeo, Ronckers, Rychetnik, Saha, Sahota, Sanderson, Santer, Santer, Sargeant, Schroeder, Scriven, Scullard, Secker-Walker, Seedhouse, Senok, Sharp, Silagy, Simmons, Simpson, Sinclair, Sippel, Smeeth, Smeeth, Smeeth, Smith, Smith, Soljak, Soljak, Spice, Springett, Starfield, Starfield, Stead, Stead, Subramanian, Summers, Sutherland, Sweeney, Syson-Nibbs, Taggart, Taket, Tannahill, Taylor, Thomas, Thomas, Thorlby, Toon, Trueman, Tsianakas, Tudor-Hart, Tulloch, Turton, Twardella, Twigg, Ulbricht, van Gerwen, Van Lerberghe, Vogt, Vogt, Wainwright, Walker, Waller, Wanless, Ward, Warren, Waters, Watson, Watson, Watson, Watt, Watt, Watt, Weiler, Weiss, West, White, White, Whitehead, Whitehead, Wilkes, Wilkinson, Wilson, Wilson, Wonderling, Wood, Woodrow, Woolthuis, Wynn, Young, Zuvekas, Zwar +476 morecore +3 more sourcesClass IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio +13 morewiley +1 more sourceNormalizing daily awakening and breathing coordination at 15 heterogenous ICUs: a multicenter post-implementation survey
Implementation Science CommunicationsBackground Despite high post-implementation adherence, clinicians may have unresolved questions or concerns regarding use of a protocol to standardize routine daily coordination of the spontaneous awakening trial (SAT) and spontaneous breathing trial ...Andrew J. Knighton, Jacob Kean, Ithan D. Peltan, Dee Lisonbee, Ashley Krueger, Doug Wolfe, Carrie M. Winberg, Corey Sillito, Christopher B. Jones, Lori Carpenter, Jason R. Jacobs, Lindsay Leither, Richard Holubkov, Colin K. Grissom, Raj Srivastava +14 moredoaj +1 more sourceDual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix +13 morewiley +1 more sourcePerspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman +13 morewiley +1 more sourceNext‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner +4 morewiley +1 more source
