Results 101 to 110 of about 1,464,526 (284)

Exploring the evidence base for national and regional policy interventions to combat resistance [PDF]

, 2015
The effectiveness of existing policies to control antimicrobial resistance is not yet fully understood. A strengthened evidence base is needed to inform effective policy interventions across countries with different income levels and the human health and
Aarestrup, Aarestrup, Ahuja, Aidara-Kane, Alimuddin Zumla, Allegranzi, Allegranzi, Amábile-Cuevas, Anthony D So, Anthony Kessel, Baertlein, Belongia, Belongia, Bushnell, Catley, Catley, Cheng, Coenen, Crowther-Gibson, Dagan, Datema, Davey, David L Heymann, De Boeck, Earnshaw, Emmeline J Buckley, Fazal K Dar, Finkelstein, Fätkenheuer, Gerber, Govin Permanand, Grave, Grave, Grazia Caleo, Grundmann, Hammerum, Hanne Bak Pedersen, Harbarth, Haydar Giha, Hennessy, Henry Lishi Li, Heuer, Holloway, Huttner, Huttner, Jack, Jasper Littmann, John-Arne Røttingen, Jørgen Schlundt, Kariuki, Katakweba, Khalid M Bindayna, Khan, Komolafe, Kümmerer, Little, Luoto, Mandal, Mark Rweyemamu, Marti, McNulty, Mishal Khan, Mitj, Mohammed Shahid, Moyane, Mshana, Nisi, Ogan, Okeke, Okeke, Okeke, Osman A Dar, Parry, Pittet, Pletz, Radley, Ranji, Richard Kock, Rumina Hasan, Silverman, Simonsen, Song, Speksnijder, Spurling, Stephan Harbarth, Vanden Eng, Vernet, Versporten, Versporten, Viberg, Vlieghe, Walt, Xiao, Zingg   +93 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Construyendo un marco de evaluación de la atención primaria de la salud para Latinoamérica Building a PHC evaluation framework for Latin America

Salud Pública de México, 2010
OBJETIVO: Determinar la claridad, relevancia y pertinencia de una estrategia de evaluación de la atención primaria de la salud en distintos subsistemas de salud. MATERIAL Y MÉTODOS: La estrategia fue evaluada mediante talleres con tomadores de decisiones
Natalia Yavich, Ernesto Pablo Báscolo, Jeannie Haggerty   +2 more
doaj  

Evaluating the implementation, mechanisms of effect and context of an integrated care intervention for vulnerable families in Central Sydney Australia: A research framework

International Journal of Integrated Care, 2019
Introduction:  In March 2014, the New South Wales (NSW) Government (Australia) announced the NSW Integrated Care Strategy.  The NSW Government’s Integrated Care Strategy funding enabled the establishment of an integrated care initiative called Healthy ...
John Eastwood, Susan Woolfenden, Erin Miller, Miranda Shaw, Pankaj Garg, Hueiming Liu, Denise De Souza, Roelof Ettema   +7 more
doaj   +1 more source

"Positive Youth Justice Initiative Phase I Implementation Evaluation" [PDF]

, 2016
Sierra Health Foundation launched the Positive Youth Justice Initiative (PYJI) in 2012 with the goal of supporting California counties to change the way they approach and work with justice-involved youth. Through an integrated model that invests in youth,

core  

A systematic literature review of cloud computing in eHealth

, 2014
Cloud computing in eHealth is an emerging area for only few years. There needs to identify the state of the art and pinpoint challenges and possible directions for researchers and applications developers.
Bai, Guohua, Hu, Yan
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Through Mintzberg’s glasses: a fresh look at the organization of ministries of health

Bulletin of the World Health Organization, 2000
In 1987, district health care policies were officially adopted by a majority of developing countries. Many operational problems constraining implementation of such policies have subsequently been identified, most of which are attributable to well-known ...
Jean-Pierre Unger, Jean Macq, François Bredo, Marleen Boelaert   +3 more
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Enhancing collaborative international partnerships in healthcare – a systematic review of insights, challenges, and pathways to sustainability

Social Sciences and Humanities Open
The global health burden in developing countries remains a pressing concern, exacerbated by a complex interplay of socioeconomic, environmental, and healthcare system factors. International partnerships have emerged as pivotal mechanisms to alleviate the
Salma Arabi, Kerryn Butler-Henderson, Sandra Jones, Dein Vindigni   +3 more
doaj   +1 more source