Results 111 to 120 of about 1,464,526 (284)

Does money matter ? The effects of cash transfers on child health and development in rural Ecuador [PDF]

The authors examine how a government-run cash transfer program targeted to poor mothers in rural Ecuador influenced the health and development of their children.
Paxson, Christina, Schady, Norbert
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Required Structures for Family Physician Program to Achieving Service Quality Dimensions in Primary Health Care: a systematic review

پیاورد سلامت, 2021
Background and Aim: In recent years, the family physician plan has been implemented as a main strategy of health system in Iran. Therefore, the necessity to reform organizational structure based on experiences of other countries is felt more than before.
Ali Reza Heidarian Naeini, Ghahraman Mahmoodi Alemi, Jamshid Yazdani Charati   +2 more
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Addressing the Mental Health Needs of Older People in Prison: Development of an Initial Programme Theory (IPT) Based on Realist Synthesis

Mental Health Science
The mental health needs of older people in prison (OPiP) are considerable but remain overlooked. This review aimed to develop an Initial Programme Theory (IPT) to understand how the mental health needs of OPiP can be addressed and how mental health care ...
Lee D. Mulligan, Deborah Buck, Falaq Ghafur, Joshua Southworth, Matilda Minchin, Jenny Shaw, Jane Senior, Katrina Forsyth   +7 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Unlocking the mechanisms of change in the MAMAACT intervention to reduce ethnic disparity in stillbirth and newborns' health: integration of evaluation findings

Frontiers in Health Services
Ethnic disparities in stillbirth exist in Europe and suboptimal care due to miscommunication is one contributing cause. The MAMAACT intervention aimed to reduce ethnic disparity in stillbirth and newborns' health through improved management of pregnancy ...
Sarah Fredsted Villadsen, Helle Johnsen, Trine Damsted Rasmussen, Claus Thorn Ekstrøm, Janne Sørensen, Elie Azria, Janet Rich-Edwards, Birgitta Essén, Ulla Christensen, Signe Smith Jervelund, Anne-Marie Nybo Andersen   +10 more
doaj   +1 more source

[Realistic evaluation mechanisms in primary health care interventions in rural and marginal urban populationsMecanismos de avaliação realistas em intervenções de atenção primária à saúde em populações rurais e urbanas periféricas].

Revista panamericana de salud publica = Pan American journal of public health
Identify mechanisms reported in primary health care (PHC) interventions in rural and marginal urban populations from 1997 to 2019.A scoping review was used to identify the literature. The literature search was conducted using the Medline (PubMed and Ovid), Global Health, Embase, Web of Science, Scopus, and Lilacs databases.
Lina María, García-Zapata, María Teresa, Alarcón-Gil   +1 more
openaire   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Healthcare queueing models. [PDF]

Healthcare systems differ intrinsically from manufacturing systems. As such, they require a distinct modeling approach. In this article, we show how to construct a queueing model of a general class of healthcare systems.
Creemers, Stefan, Lambrecht, Marc
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