Results 201 to 210 of about 1,464,526 (284)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Securing Federated Learning With Blockchain in the Medical Field: Systematic Literature Review.

J Med Internet Res
Wang X, Xie Y, Chen X, Yang J, Li R, Gao W, Yan Z, Zhou H, Ye Z.   +8 more
europepmc   +1 more source

Realist Lens and the Theory-of-change Approaches to Evaluate the Impact of Digitally Driven Capacity-building Initiatives for Mental Health in India: A Conceptual Framework. [PDF]

Indian J Psychol Med
Sabhahit GG, V S, Megha C N, Komala T Y, Hegde PR, Patley R, Manjunatha N, Kumar CN, Math SB.   +8 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Cluster randomised controlled trial for service delivery redesign of primary care for people with diabetes: study protocol. [PDF]

BMJ Open
Mazzoni A, Roberti J, Guglielmino M, Jorro-Baron F, Mazzaresi Y, Falaschi A, Alvarez J, Gibbons L, Leslie HH, Silva C, Garcia PJ, Garcia-Elorrio E.   +11 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Integrating systems and implementation science in modeling and evaluating complex health interventions: methodological reflections from service delivery redesign in Kakamega, Kenya. [PDF]

Health Policy Plan
Alonge O, Ji T, Chen M, Igusa T.
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Optimising delivery of integrated palliative care and heart failure services: A realist evaluation protocol (PalliatHeartSynthesis II). [PDF]

PLoS One
McConnell T, Scott D, Wong G, Hill L, Johnson MJ, Millerick Y, Ross J, Atkinson C, Cooper L, Burden J, Campbell R, Kerr A, Thomas H, Reid J.   +13 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source