Results 41 to 50 of about 1,464,526 (284)

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

(Des)judicialização da saúde: mediação e diálogos interinstitucionais

Revista Bioética
Resumo Partindo do exame da legislação, jurisprudência e doutrina, analisa-se o trajeto usual dos pedidos de medicamentos no Sistema Único de Saúde, enfatizando-se solicitações fora da Relação Nacional de Medicamentos Essenciais.
Alexandre Barbosa da Silva, Gabriel Schulman   +1 more
doaj   +1 more source

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
A Mercat, AM Cheung, C Brun-Buisson, C Rossi, Cecilia M O’Kane, Christine McNally, Daniel F McAuley, DJ Kor, Excellence NIfHaC, F Gao Smith, Gavin D Perkins, GD Rubenfeld, GR Bernard, Grainne Crealey, Irish Critical Care Trials Group, John G Laffey, KF Schulz, LA Curtis, Lynn Murphy, M Shyamsundar, MA Matthay, Mark Cross, Michael Stevenson, MS Herridge, RG Brower, S Harvey, SE Erickson, T Craig, The ARDS Network investigators, The EuroQol Group, TR Craig, TW Felton   +31 more
core   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Burnout syndrome and wellbeing in anesthesiologists: the importance of emotion regulation strategies [PDF]

, 2017
Anesthesiologists face stressful working conditions that can culminate in burnout syndrome. Despite various studies and protective measures which have attempted to prevent this situation, burnout continues to be a problem within the profession, impacting
Lapa, TA, Madeira, FM, Pinto-Gouveia, J, Viana, JS   +3 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Does the engagement of clinicians and organisations in research improve healthcare performance: a three-stage review [PDF]

, 2015
Objective: There is a widely held assumption that engagement by clinicians and healthcare organisations in research improves healthcare performance at various levels, but little direct empirical evidence has previously been collated.
Abraham, Bennett, Bernard, Boaz, Bowen, Carpenter, Chaney, Clarke, Cohen, Cooke, Darbyshire, Denis, Department of Health, Department of Health, Dixon-Woods, Du Bois, Ducharme, Francis, Goldberg, Greenhalgh, Hall, Hanney, Jagosh, Kizer, Kizer, Knudsen, Kuehlein, Laliberte, Lewin, Liberati, Lomas, Majumdar, Minasian, NHS Confederation, Oxman, Pincus, Pons, Puoane, Rich, Rochon, Rochon, Rogers, Selby, Smee, Soper, Spurgeon, Teal, Walshe, Whicher, Zerhouni   +49 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

How to Build a Quality, Efficient and Integrated Health System [PDF]

Zhongguo quanke yixue
Building a high-quality and efficient people centered integrated care system with Chinese characteristics crucial for implementing the Healthy China strategy and essential for the high-quality development of the healthcare system.
LIANG Wannian
doaj   +1 more source

Population health management guiding principles to stimulate collaboration and improve pharmaceutical care [PDF]

, 2018
Purpose: A range of strategies to improve pharmaceutical care has been implemented by population health management (PHM) initiatives. However, which strategies generate the desired outcomes is largely unknown.
Steenkamer, B. (Betty), Baan, C.A. (Caroline), Putters, K. (Kim), Oers, H.A.M. (Hans), Drewes, H.W. (Hanneke W.)   +4 more
core   +1 more source