Results 51 to 60 of about 1,464,526 (284)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

IT development in radiology - an ESR update on the Digital Imaging Adoption Model (DIAM)

Insights into Imaging, 2019
The Digital Imaging Adoption Model (DIAM), a joint project established in 2016 by the European Society of Radiology (ESR) and the Healthcare Information and Management Systems Society (HIMSS), is designed to assist imaging institutions in implementing ...
European Society of Radiology (ESR)
doaj   +1 more source

Evaluating Large-Scale Integrated Care Projects: The Development of a Protocol for a Mixed Methods Realist Evaluation Study in Belgium

International Journal of Integrated Care, 2020
Background: The twelve Integrated Care Program pilot projects (ICPs) created by the government plan ‘'Integrated Care for Better Health'’ aim to achieve four outcome types (the Quadruple Aim) for people with chronic diseases in Belgium: improved ...
Geert Goderis, Elien Colman, Lucia Alvarez Irusta, Ann Van Hecke, Benoit Petré, Dirk Devroey, Elias Van Deun, Kristof Faes, Nathan Charlier, Nick Verhaeghe, Roy Remmen, Sibyl Anthierens, Walter Sermeus, Jean Macq   +13 more
doaj   +1 more source

Using interactive workshops to prompt knowledge exchange: a realist evaluation of a knowledge to action initiative [PDF]

, 2014
INTRODUCTION: Interactive workshops are often the default mechanism for sharing knowledge across professional and sector boundaries; yet we understand little about if, and how, they work.
Hunter, David J., Rushmer, Rosemary, Steven, Alison   +2 more
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Process Evaluation of an Implementation Trial: Design, Rationale, and Early Lessons Learnt From an International Cluster Clinical Trial in Intracerebral Hemorrhage

Frontiers in Medicine, 2022
BackgroundThe third INTEnsive care bundle with blood pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT3) is an ongoing, international, multicenter, stepped-wedge cluster, prospective, randomized, open, blinded endpoint assessed trial ...
Menglu Ouyang, Craig S. Anderson, Craig S. Anderson, Craig S. Anderson, Craig S. Anderson, Lili Song, Lili Song, Alejandra Malavera, Stephen Jan, Guojuan Cheng, Honglin Chu, Xin Hu, Lu Ma, Xiaoying Chen, Chao You, Hueiming Liu   +15 more
doaj   +1 more source

The reflective component of the Mellow Bumps parenting intervention: Implementation, engagement and mechanisms of change [PDF]

, 2019
Understanding why parenting programmes work or do not work, and for whom, is crucial for development of more effective parenting interventions. In this paper we focus on a specific component of Mellow Bumps: reflection on one’s own childhood/past/life ...
Buston, Katie, Henderson , Marion, O'Brien, Rosaleen, Wight , Danny   +3 more
core   +5 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source