Results 61 to 70 of about 1,464,526 (284)

Sig realist research design and evaluation for integrated care, wokring meeting

International Journal of Integrated Care, 2019
Background: Realist philosophy and methodology is increasingly being explicitly used in the field of integrated care to research the extant context, structure and mechanisms at play, and to design and evaluation interventions.
John Eastwood, Erin Miller, Roelof Ettema   +2 more
doaj   +1 more source

Using non-participant observation to uncover mechanisms: insights from a realist evaluation [PDF]

, 2019
This article outlines how a realist evaluation of dementia care in hospitals used non-participant observation to support the refinement and testing of mechanisms likely to lead to the use of person-centred care. We found that comments and explanations of
Bhaskar R, Claire Goodman, Frances Bunn, Handley M, Holloway I, Jennifer Lynch, McGaughey J, Melanie Handley, Pawson R, Silverman D   +9 more
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Randomised controlled trials of complex interventions and large-scale transformation of services [PDF]

, 2016
Complex interventions and large-scale transformations of services are necessary to meet the health-care challenges of the 21st century. However, the evaluation of these types of interventions is challenging and requires methodological development ...
Barratt, Helen, Bower, Peter, Campbell, Marion, Moore, Laurence, Zwarenstein, Merrick   +4 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Translation and cultural adaptation to the Brazilian context of the Organizational Readiness to Change Assessment scale [PDF]

Epidemiologia e Serviços de Saúde
Objectives: To translate and culturally adapt the Organizational Readiness to Change Assessment scale to the Brazilian context. Methods: The translation and cross-cultural adaptation process took place in six stages: 1) authorization from the author ...
Tânia R. Bertoldo Benedetti, Thaís Fávero Alves, Natalia Santos, Cassiano Ricardo Rech, Gaia Salvador Claumann, Fabiana Brito Silva   +5 more
doaj   +4 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Cost-effectiveness of prehabilitation of elderly frail or pre-frail patients prior to elective surgery (PRAEP-GO) versus usual care – Protocol for a health economic evaluation alongside a randomized controlled trial

BMC Geriatrics
Background Prehabilitation aims to improve patients' functional capacity before surgery to reduce perioperative complications, promote recovery and decrease probability of disability.
Helene Eckhardt, Wilm Quentin, Julia Silzle, Reinhard Busse, Tanja Rombey   +4 more
doaj   +1 more source

Using realist evaluation to assess primary healthcare teams’ responses to intimate partner violence in Spain

Gaceta Sanitaria, 2015
Objective: Few evaluations have assessed the factors triggering an adequate health care response to intimate partner violence. This article aimed to: 1) describe a realist evaluation carried out in Spain to ascertain why, how and under what circumstances
Isabel Goicolea, Anna-Karin Hurtig, Miguel San Sebastian, Bruno Marchal, Carmen Vives-Cases   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source