Results 81 to 90 of about 1,464,526 (284)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Calidad del expediente clínico. Evaluación de parámetros medicolegales

Revista de Ciencias Forenses de Honduras
Objetivo: Analizar el nivel de cumplimiento de parámetros de calidad en una muestra de los expedientes clínicos de un hospital hondureño. Introducción: el expediente clínico adquiere un papel jurídico al reflejar el cumplimiento de los principales ...
Bárbara Galeas Matus
doaj   +1 more source

Workshop on the Development and Evaluation of Digital Therapeutics for Health Behavior Change: Science, Methods, and Projects

JMIR Mental Health, 2020
The health care field has integrated advances into digital technology at an accelerating pace to improve health behavior, health care delivery, and cost-effectiveness of care. The realm of behavioral science has embraced this evolution of digital health,
Budney, Alan J, Marsch, Lisa A, Aklin, Will M, Borodovsky, Jacob T, Brunette, Mary F, Campbell, Andrew T, Dallery, Jesse, Kotz, David, Knapp, Ashley A, Lord, Sarah E, Nunes, Edward V, Scherer, Emily A, Stanger, Catherine, Torrey, William C   +13 more
doaj   +1 more source

Performance-based financing as a health system reform : mapping the key dimensions for monitoring and evaluation [PDF]

, 2013
Peer reviewedPublisher ...
A Aryankhesal, A Fiszbein, AIDSTAR-Two-project, B Loevinsohn, B Loevinsohn, B Meessen, B Meessen, B Meessen, B Meessen, Bruno Meessen, C Vermeersch, D de Savigny, E Morin, F Ssengooba, G Nsengiyumva, György Fritsche, J Kutzin, J Macq, J Peabody, J Toonen, JB Falisse, Jean Kagubare, Jurrien Toonen, K Sheikh, Kelsey Vaughan, M Bertone, M Roberts, N Birdsall, O Basenya, P Basinga, P Gertler, P Musagalusa, P Musgrove, R Eichler, R Eichler, R Soeters, R Soeters, S Fox, S Hoffman, S Mayaka, S Witter, S Witter, S Witter, Sophie Witter, World Health Organisation   +44 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Indicadores de qualidade para serviços de audiologia

Audiology: Communication Research
OBJETIVO: Construir indicadores de qualidade para Audiologia Clínica, sob a ótica do usuário. MÉTODOS: Trata-se de um estudo transversal, realizado por meio de pesquisa de satisfação, aplicada por meio de 13 perguntas (sendo apenas uma aberta).
Erica Miranda da Silva Bacchetti, Renata Akiyama, Ricardo Ferreira Bento, Alessandra Giannella Samelli   +3 more
doaj  

The performance of health workers in Ethiopia - results from qualitative research [PDF]

Insufficient attention has been paid to understanding what determines the performance of health workers and how they make labor market choices. This paper reports on findings from focus group discussions with both health workers and users of health ...
Lemma, Teigist, Lindelow, Magnus, Serneels, Pieter   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source