Results 141 to 150 of about 918,627 (316)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Economic evaluation of complex multidimensional health services : the case of palliative day care [PDF]

Palliative day care is offered to patients with a life-limiting illness. It provides a range of services to meet the varying needs of individuals. Consequently, the service is multidimensional and the outcomes are hard to define.
Douglas, Hannah-Rose
core   +1 more source

Availability of Periodontal Instruments, Procedures, and Specialized Referral in Primary Health Care in Brazil

Pesquisa Brasileira em Odontopediatria e Clínica Integrada
Objective: To analyze the availability of periodontal instruments, services, and specialized referrals in Primary Health Care and compare Brazilian geographical regions.
Manoelito Ferreira Silva-Junior, Elisa Aparecida da Silva Freitas, Fabiana Ribeiro Marques, Mabelle de Freitas Monteiro, Marcia Helena Baldani   +4 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Pre-admission assessment of elderly applicants to long-term care [PDF]

, 2003
Aim: to identify whether pre-admission assessment of elderly applicants could be an effective means of identifying actual need for long term care Methods: 105 applicants to long term care were assessed at source for suitability for admission.
Dimech, Joseph, Fiorini, Anthony
core  

Avaliação da qualidade de assistência primária à saúde em localidade urbana da região sul do Brasil

Revista de Saúde Pública
Foi estudada transversalmente uma amostra de 10% dos pacientes que consultaram em dois Postos de Assistência Primária à Saúde da Cidade de Pelotas (RS), Brasil, com o objetivo de avaliar, qualitativamente, o cuidado à saúde que estava sendo oferecido ...
Iná S. Halal, Felipe Sparrenberger, Anete M. Bertoni, Carla Ciacomet, Carlos E. Seibel, Flávia M. Lahude, Gilson A. Magalhães, Lirio Barreto, Rita C.A. Lira   +8 more
doaj  

Health Care Assessment of Health Care Delivery and Outcome- A West African Review

Saudi Journal of Medicine, 2019
Lydia T. Cassell, Ayun K. Cassell
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Governance and health systems performance: Exploring the association and pathways

, 2012
This thesis was submitted for the degree of Doctor of Public Health and awarded by Brunel University.There has been an increase in empirical evidence indicating an association between governance and health systems, suggesting that better governed ...
Olafsdottir, Anne
core