Results 71 to 80 of about 487,914 (265)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

APPROCHE SOCIOLOGIQUE DE LA QUESTION DES INEGALITES D’ACCES AUX SOINS EN ALGERIE

Revue des Sciences Humaines, 2017
From a multiple sources of information on official statistics and major health surveys carried out in Algeria between 1990 and 2006, this article examines the health situation in Algeria on the issue of unequal access to healthcare, which is the result ...
Abdelkkrim BOULEDROUA
doaj  

Estimating malaria burden among pregnant women using data from antenatal care centres in Tanzania: a population-based study

The Lancet Global Health, 2019
Summary: Background: More timely estimates of malaria prevalence are needed to inform optimal control strategies and measure progress. Since 2014, Tanzania has implemented nationwide malaria screening for all pregnant women within the antenatal care ...
Chonge Kitojo, MBA, Julie R Gutman, MD, Frank Chacky, MSc, Emmanuel Kigadye, PhD, Sigsbert Mkude, MD, Renata Mandike, DDS, Ally Mohamed, MD, Erik J Reaves, DO, Patrick Walker, PhD, Deus S Ishengoma, PhD   +9 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Adaptation and Validation of the Primary Care Assessment Tool (PCAT-A10) in the Peruvian Population

Iatreia
Introduction: Primary care is the foundation of an effective health system; therefore, it is necessary to evaluate its performance from the population's perspective with validated and easily administered instruments. Objective: To adapt and validate the
Becerra-Canales, Bladimir , Hernández-Huaripaucar, Edgar, Melgarejo-Ángeles, Wilder Enrique, Córdova-Delgado, Margarita, Puza-Mendoza, Gladys, Pastor-Ramírez, Norma, Becerra-Huamán, Domizbeth   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Assessment of quality of primary care with facility surveys: a descriptive analysis in ten low-income and middle-income countries

The Lancet Global Health, 2018
Summary: Background: Primary care has the potential to address a large proportion of people's health needs, promote equity, and contain costs, but only if it provides high-quality health services that people want to use.
Erlyn K Macarayan, PhD, Anna D Gage, MSc, Svetlana V Doubova, MD, Frederico Guanais, PhD, Ephrem T Lemango, MD, Youssoupha Ndiaye, MD, Peter Waiswa, MD, Margaret E Kruk, MD   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Socioeconomic inequalities in the use of dental services in Brazil: an analysis of the 2019 National Health Survey

Revista Brasileira de Epidemiologia
: Objective: To describe the prevalence of use of dental services in Brazil according to states and the Federal District and its relationship with socioeconomic variables and types of services, based on the 2019 National Health Survey. Methods: This is
Maria Laura Braccini Fagundes, Lucelen Fontoura Bastos, Orlando Luiz do Amaral Júnior, Gabriele Rissotto Menegazzo, Amanda Ramos da Cunha, Caroline Stein, Lucas Guimarães Abreu, Fernando Neves Hugo, Jessye Melgarejo do Amaral Giordani, Deborah Carvalho Malta, Betine Pinto Moehlecke Iser   +10 more
doaj   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source