Results 171 to 180 of about 1,413,593 (317)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Deltacron: A new public health concern

APIK Journal of Internal Medicine, 2023
Pathum Sookaromdee, Viroj Wiwanitkit
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Mental Health National Service Framework

, 2003
Includes bibliographical referencesAvailable from British Library Document Supply Centre- DSC:3864.
Alcohol Concern. Mental Health and Alcohol Misuse Project (United Kingdom)
core  

Stigmatizing bioterrorism as a public health concern: The case of anthrax in US media. [PDF]

BMC Public Health
Dabezies JM, Freeman N, Muñoz Cassolis N, Rakowski JJ, Xu EJ, Gore ML.   +5 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Obstetric violence: A public health concern

Health Science Reports, 2023
Majani M. Edward, Zakia Kibanda
doaj   +1 more source

The Impact of Microplastics on Human Health: An Urgent Public Health Concern. [PDF]

J Clin Pract Res
Kökoğlu K, Mıhçıokur H, Uyanık İ.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A weak health response is increasing the risk of excess mortality as food crisis worsens in Somalia

Conflict and Health, 2017
Andrew Seal, Francesco Checchi, Nancy Balfour, Abdi-Rashid Haji Nur, Mohamed Jelle   +4 more
doaj   +1 more source