Results 51 to 60 of about 299,746 (312)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

New England Regional Health Equity Profile & Call to Action [PDF]

, 2016
Good health is a foundation that allows people to participate in the most important aspects of life. The purpose of the New England Regional Health Equity Profile and Call to Action is to identify where differences in good health exist among racial ...
Chiu, K., Data, Research, and Evaluation Committee of the Region I Health Equity Council, Drum, Charles E., Phillips, Kimberly G.   +3 more
core   +1 more source

Development Through Empowerment: Delivering Effective Public Services - A Literature Review [PDF]

, 2013
This paper reviews the channels through which empowerment may improve the efficiency and quality of public service delivery, particularly in developing Asia.
Xu, Guo
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Charakter prawny rady społecznej w samodzielnym publicznym zakładzie opieki zdrowotnej

Studia Administracyjne
The basis of the conducted research is a desire to determine the legal character of social councils in independent public health care institutions, which will consequently make it possible to formulate de lege ferenda postulates improving and ...
Michał Gornowicz
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

“No matter how hot it is, you just have to do the work”: Examining farmworkers’ experiences with heat and climate change in Idaho

The Journal of Climate Change and Health
Introduction: Farmworkers are one of the populations most vulnerable to climate change. In addition to disproportionate exposure to climate-intensified hazards such as extreme heat and wildfire smoke, many farmworkers face situational and psychosocial ...
Carly Hyland, Delmy Flores, Grace Augusto, Irene Ruiz, Marielena Vega, Rulon Wood   +5 more
doaj   +1 more source

Strategy for nursing research in Sweden

Investigación y Educación en Enfermería, 2017
Sweden has about 10 million inhabitants. The responsibility for health and medical care is shared by the central government, county councils (n=20) and municipalities (n=290).1 Health care in Sweden is largely tax-funded, a system that ensures equal ...
Clara Aarts
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Strategies to Reduce the Euthanasia of Impounded Dogs and Cats Used by Councils in Victoria, Australia

Animals, 2018
Using euthanasia to manage dog and cat overpopulation causes health issues and emotional stress in employees involved, increases staff turnover, and has financial, moral and ethical ramifications for communities.
Jacquie Rand, Emily Lancaster, Georgina Inwood, Carolyn Cluderay, Linda Marston   +4 more
doaj   +1 more source