Results 41 to 50 of about 11,975,747 (264)

COVID-19 Database of public health guidance - 12 November 2021

, 2021
To inform the ongoing response to the COVID-19 pandemic, specifically, to inform the development of public health guidance to prevent the spread of COVID-19, we have created a database of COVID-19 public health guidance produced by international ...
Health Information and Quality Authority (HIQA)
core  

State-of-the-Art Review on the Application of Membrane Bioreactors for Molecular Micro-Contaminant Removal from Aquatic Environment

Membranes, 2022
In recent years, the emergence of disparate micro-contaminants in aquatic environments such as water/wastewater sources has eventuated in serious concerns about humans’ health all over the world.
My-Linh Nguyen, Ali Taghvaie Nakhjiri, Mehnaz Kamal, Abdullah Mohamed, Mohammed Algarni, Subbotina Tatyana Yu, Fu-Ming Wang, Chia-Hung Su   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

COVID-19 Database of public health guidance - 01 December 2021

, 2021
To inform the ongoing response to the COVID-19 pandemic, specifically, to inform the development of public health guidance to prevent the spread of COVID-19, we have created a database of COVID-19 public health guidance produced by international ...
Health Information and Quality Authority (HIQA)
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Scoping Review to Assess Sexual and Reproductive Health Outcomes, Challenges and Recommendations in the Context of Climate Migration

Frontiers in Global Women's Health, 2021
Background: As growing numbers of people may be forced to migrate due to climate change and variability, it is important to consider the disparate impacts on health for vulnerable populations, including sexual and reproductive health (SRH).
Kim Robin van Daalen, Sara Dada, Rita Issa, Maisoon Chowdhury, Laura Jung, Lucy Singh, Diarmuid Stokes, Miriam Orcutt, Neha S. Singh   +8 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Willing, but unequally: Indigenous identity influences participation in Alzheimer's disease biomarker research in Chile

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION This study aimed to compare the willingness to use Alzheimer's disease (AD) predictive–diagnostic procedures between Mapuche (Indigenous) and non‐Indigenous older adults in Chile.
José M. Aravena, Rodrigo Saguez, Moisés H. Sandoval, Carolina Herrera, Cecilia Albala, Patricio Fuentes   +5 more
doaj   +1 more source

Eclipsed by the Prostate: Expanding Testicular Cancer Scholarship Through Years of Potential Life Lost and Economic Productivity

American Journal of Men's Health, 2017
Men’s health has been generalized as prostate cancer (PCa) with a supporting cast of other health issues, such as testicular cancer (TCa). As a result, research and scholarship in these supporting topical areas may not receive appropriate attention.This ...
Michael J. Rovito PhD, CHES, FMHI
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source