Results 51 to 60 of about 914,199 (275)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Birth Cohort Variations Across Functional Knowledge of HIV Prevention Strategies, Perceived Risk, and HIV-Associated Behaviors Among Gay, Bisexual, and Other Men Who Have Sex With Men in the United States

American Journal of Men's Health, 2018
Gay, bisexual, and other men who have sex with men (GBMSM) in the United States remain heavily impacted by HIV. The purpose of this study was to describe intergenerational differences in functional knowledge of HIV prevention strategies, perceived risk ...
Akshay Sharma MBBS, MPH, PhD, Erin M. Kahle MPH, PhD, Stephen P. Sullivan MPH, Rob Stephenson MSc, PhD   +3 more
doaj   +1 more source

Understanding the Changing Landscape of Health Disparities in Chronic Liver Diseases and Liver Cancer

Gastro Hep Advances, 2023
Liver disease and liver cancer disparities in the United States are reflective of complex multiple determinants of health. This review describes the disproportionate burden of liver disease and liver cancer among racial, ethnic, sexual, and gender ...
Olga M. Herren, Arielle S. Gillman, Vanessa J. Marshall, Rina Das   +3 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Sharing of Grant Funds between Academic Institutions and ­Community Partners in Community‐Based Participatory Research

Clinical and Translational Science, 2014
Objectives To determine how grant funds are shared between academic institutions and community partners in community‐based participatory research (CBPR). Methods Review of all 62 investigator‐initiated R01 CBPR grants funded by the National Institutes of
Katrice D. Cain, Jacqueline R. Theurer, Ashwini R. Sehgal   +2 more
doaj   +1 more source

Metro Richmond Latino Health Services & Resource Guide – 2006 [PDF]

, 2006
This Guide was produced by the VCU Institute for Women’s Health, VCU Center on Health Disparities, and CLAS Act Virginia as a resource for the fall 2006 Latino Health Summit: Latino Cultures and Beliefs in Health Care.
Virginia Commonwealth University
core   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Mental health symptoms and discrimination among immigrant and US-born Hispanic or Latino adults during the COVID-19 pandemic

BMC Psychology
Background Mental health symptoms are highly stigmatized, potentially increasing the risk of experiencing discrimination, particularly within minoritized communities such as Hispanic or Latino populations.
Emmanuel A. Odame, Maryam Elhabashy, David Adzrago, Jolyna Chiangong, Cameron K. Ormiston, Faustine Williams   +5 more
doaj   +1 more source

Consumption of ultra-processed foods by foreign-born adults rise with increased levels of acculturation in the United States

Frontiers in Public Health
ObjectiveUltra-processed food (UPF) consumption has been linked to increased risks of negative health outcomes such as type 2 diabetes, obesity, and all-cause mortality.
Jennifer J. Barb, Li Yang, Euridice Martinez-Steele, Ayaan Ahmed, Patricia V. Medina, E. Michael Valencia, Anna E. Roberts, Nicole Farmer, Gwenyth R. Wallen   +8 more
doaj   +1 more source