Results 211 to 220 of about 20,380,021 (264)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
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Medical Journal of Australia, 1984
An epidemiological study involving 893 people was undertaken during the 1980/81 summer period in the Richmond and Windsor region of New South Wales to determine the incidence of swimmers and non-swimmers reporting ear, eye, skin, throat and gastrointestinal complaints. Swimmers were found to report a greater incidence of ear and eye complaints than non-
B, Powis, A, Hazzard
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An epidemiological study involving 893 people was undertaken during the 1980/81 summer period in the Richmond and Windsor region of New South Wales to determine the incidence of swimmers and non-swimmers reporting ear, eye, skin, throat and gastrointestinal complaints. Swimmers were found to report a greater incidence of ear and eye complaints than non-
B, Powis, A, Hazzard
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The Effects Of Violence On Health
Health Affairs, 2019Violence in its many forms can affect the health of people who are the targets, those who are the perpetrators, and the communities in which both live. In this article we review the literature on the health consequences of many forms of violence, including child physical and sexual abuse, intimate partner violence, elder abuse, sexual violence, youth ...
Frederick, Rivara +7 more
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The effect of health care on population health
The Lancet, 2004The health status of populations has long been a central focus for health scientists economists and policy makers. Early work from the USA and the UK established the contributions that factors such as environment and lifestyle make to population health.
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Toxicology and Industrial Health, 2008
Abstract Acrolein is a chemical used as an intermediate reactive aldehyde in chemical industry. It is used for synthesis of many organic substances, methionine production, and methyl chloride refrigerant. The general population is exposed to acrolein via smoking, second-hand smoke, exposure to wood and plastic smoke.
O, Faroon +5 more
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Abstract Acrolein is a chemical used as an intermediate reactive aldehyde in chemical industry. It is used for synthesis of many organic substances, methionine production, and methyl chloride refrigerant. The general population is exposed to acrolein via smoking, second-hand smoke, exposure to wood and plastic smoke.
O, Faroon +5 more
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Polyphenols’ Effect on Cerebrovascular Health
Current Medicinal Chemistry, 2022: Polyphenols are a wide group of plant components that include a high number of individual compounds and are present in foods, dietary supplements, and drugs. Many of them have shown pharmacological effects, are used in cardiovascular disease prevention, and not as many have been assayed in cancer treatment or co-treatment.
Luis Goya +2 more
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Health Effects of Phytoestrogens
2005Phytoestrogens are naturally occurring plant-derived phytochemicals, whose common biological roles are to protect plants from stress or to act as part of a plant's defense mechanism. Although composed of a wide group of nonsteroidal compounds of diverse structure, phytoestrogens have been shown to bind estrogen receptors and to behave as weak agonist ...
Francesco, Branca, Stefano, Lorenzetti
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Health effects of nanomaterials
Biochemical Society Transactions, 2007With the rapid growth of nanotechnology and future bulk manufacture of nanomaterials comes the need to determine, understand and counteract any adverse health effects of these materials that may occur during manufacture, during use, or accidentally. Nanotechnology is expanding rapidly and will affect many aspects of everyday life; there are already ...
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