Results 121 to 130 of about 7,937,794 (427)

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

Advanced Healthcare Materials, EarlyView.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner, Adrian Feile, Miriam Alb, Michael Hudecek, Philip Hewitt, Alexander S. Mosig   +5 more
wiley   +1 more source

Lovo‐cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB‐206 study

American Journal of Hematology, Volume 98, Issue 1, Page 11-22, January 2023., 2023
Treatment process evolution. *The target TNC for BMH was ≥6 × 108/kg per patient. The Group B1 patient received lovo‐cel produced using both the original and refined manufacturing process, and the Group B2 patient received lovo‐cel produced using only the refined manufacturing process.
Julie Kanter, Alexis A. Thompson, Francis J. Pierciey Jr, Matthew Hsieh, Naoya Uchida, Philippe Leboulch, Manfred Schmidt, Melissa Bonner, Ruiting Guo, Alex Miller, Jean‐Antoine Ribeil, David Davidson, Mohammed Asmal, Mark C. Walters, John F. Tisdale   +14 more
wiley   +1 more source

Resilience and coping strategies of older adults in Hong Kong during COVID-19 pandemic: a mixed methods study

BMC Geriatrics, 2022
Background Despite the adverse physical health impact of COVID-19 on older adults, whether they are psychosocially vulnerable under the pandemic remains debatable.
Siu-Ming Chan, Gary Ka-Ki Chung, Yat-Hang Chan, Roger Yat-Nork Chung, Hung Wong, Eng Kiong Yeoh, Jean Woo   +6 more
doaj   +1 more source

Equity Promotion in Online Resource Allocation [PDF]

arXiv, 2021
We consider online resource allocation under a typical non-profit setting, where limited or even scarce resources are administered by a not-for-profit organization like a government. We focus on the internal-equity by assuming that arriving requesters are homogeneous in terms of their external factors like demands but heterogeneous for their internal ...
arxiv  

Human rights in health systems frameworks: what is there, what is missing and why does it matter?

, 2012
Global initiatives and recent G8 commitments to health systems strengthening have brought increased attention to factors affecting health system performance.
Ahmed, Shahira, Bogecho, Dina, Ferguson, Laura, Gruskin, Sofia, Hanefeld, Johanna, Maccarthy, Sarah, Raad, Zyde, Steiner, Riley   +7 more
core   +1 more source

Rethinking COVID-19 Vulnerability: A Call for LGBTQ+ Im/migrant Health Equity in the United States During and After a Pandemic

Health Equity, 2020
Public health responses to the coronavirus disease 2019 (COVID-19) pandemic have emphasized older adults' vulnerability, but this obfuscates the social and political root causes of health inequity.
Nolan S. Kline
semanticscholar   +1 more source

Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery

Advanced Healthcare Materials, EarlyView.
Lipid nanoparticles (LNPs) have rapidly become the delivery system of choice for RNA therapeutics. Here, a rational design approach is taken to improve the effectiveness of LNPs based on an ionizable thioether lipid library. The incorporation of unsaturated tails and bulkier, hydrophobic head groups significantly enhances their functionality and ...
Eleni Samaridou, Johanna Simon, Moritz Beck‐Broichsitter, Gary Davidson, Pavel A. Levkin   +4 more
wiley   +1 more source

The influence of gender-based perceptions on females joining a bachelor of medicine, bachelor of surgery in Rwanda

BMC Medical Education
Through progressive policies, Rwanda has made significant strides in promoting girls’ education and empowerment. However, female enrollment in Bachelor of Medicine and Bachelor of Surgery (MBBS) programs remains disproportionately low.
Tsion Yohannes Waka, Deborah Umucyo, Arlene Nishimwe, Abigail J. Yoon, Kara L. Neil   +4 more
doaj   +1 more source

Exploring drivers and prevention strategies for sexual violence among adolescent girls and young women in Kicukiro, Rwanda

Frontiers in Reproductive Health
IntroductionSexual violence against adolescent girls and young women (AGYW) is a pervasive issue globally, with particularly high prevalence in sub-Saharan Africa.
Wongani Patricia Kawonga, Sam M. Livingstone, Augustine Ndaimani, Jean Pierre Sibomana, Tsion Yohannes Waka, Maxwell Mhlanga, Andrew Mclellan   +6 more
doaj   +1 more source

Recommendations for Health Equity and Virtual Care Arising From the COVID-19 Pandemic: Narrative Review

JMIR Formative Research, 2020
Background The COVID-19 health crisis has disproportionately impacted populations who have been historically marginalized in health care and public health, including low-income and racial and ethnic minority groups.
J. Shaw, LaPrincess C. Brewer, T. Veinot
semanticscholar   +1 more source