Results 191 to 200 of about 3,040,148 (317)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

[Evaluation of the performance of health services].

Revista de saude publica, 1991
Recent literature (up to 1988) on health service assessment in general and especially on hospital service assessment is reviewed, with special attention to its conceptual and methodological aspects. The history of this process is also examined, from the first attempts by the American College of Surgeons, through the Joint Commission for Hospital ...
openaire   +2 more sources

Avaliação da atenção à saúde através da investigação de óbitos infantis

Cadernos de Saúde Pública
Foram investigados todos os óbitos de crianças menores de um ano residentes no Distrito Sanitário de Pau da Lima, Município de Salvador, Brasil, no ano de 1991, através de consultas aos respectivos prontuários hospitalares e visitas domiciliares.
Vera L. Almeida Formigli, Lígia Maria Vieira da Silva, Alfonso J. P. Cerdeira, Cristiane M. F. Pinto, Renata S. A. Oliveira, Alessandra C. Caldas, Maria José B. Vilas Boas, Anderson C. Fonseca, Leda Solano F. Souza, Luciana R. Silva, Maria do Socorro F. Paes   +10 more
doaj  

Smart Health Evaluation for Lithium-Ion Battery With Super-Short-Segment Charging. [PDF]

Adv Sci (Weinh)
Li Q, Wei Z, He H, Shen J, Li Y, Yang X, Vilathgamuwa M.   +6 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Digital Health Evaluation of Canadians With Physical Disabilities Compared to Those Without Chronic Conditions. [PDF]

Cureus
DaSilva V, Meyer JM, Nippak P, Begum H.
europepmc   +1 more source

Retracted: Mental Health Evaluation Based on Visual Analysis Technology. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Comparison of Acute Physiology and Chronic Health Evaluation (APACHE) II, Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (POSSUM), and Surgical Apgar Score in Patients Undergoing Emergency Laparotomy. [PDF]

Cureus
Marahanumaiah S, Reddy PV, Jagannath K, Galani N, Suresh N.   +4 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source