Results 51 to 60 of about 8,378 (214)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Out-of-pocket expenditure for hypertension care: a population-based study in low-income urban Medellin, Colombia

open access: yesGlobal Health Action, 2020
Background Hypertension requires life-long medical care, which may cause economic burden and even lead to catastrophic health expenditure. Objective To estimate the extent of out-of-pocket expenditure for hypertension care at a population level and its ...
Esteban Londoño Agudelo   +7 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

The Impact of Air Pollution on Healthcare Expenditure for Respiratory Diseases: Evidence from the People’s Republic of  China

open access: yesRisk Management and Healthcare Policy, 2020
Lele Li,1,* Tiantian Du,2,* Chi Zhang3 1School of Public Policy and Management, Tsinghua University, Beijing 100084, People’s Republic of China; 2Institute for Hospital Management, Tsinghua University, Shenzhen 518055, People’s Republic of ...
Li L, Du T, Zhang C
doaj  

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

Understanding the heterogeneity in healthcare expenditure in India

open access: yesBMC Medical Research Methodology
Health expenditure is indicative of the financial burden of health care and serves as a yardstick of health system performance. However, health expenditure may be shaped by multiple factors such as prevalence of morbidity, income inequality and above all,
Srikanth Reddy Umenthala   +2 more
doaj   +1 more source

Determinants and Equity Evaluation for Health Expenditure Among Patients with Rare Diseases in China

open access: yesChinese Medical Journal, 2016
Background: China has not established social security system for rare diseases. Rare diseases could easily impoverish patients and their families. Little research has studied the equity and accessibility of health services for patients with rare diseases
Xiao-Xiong Xin   +3 more
doaj   +1 more source

Health and Household Expenditures

open access: yes, 2018
We examine the effect of health on household expenditures in the Netherlandsbetween 2009 and 2017, a period that is characterized by significant increases in out-of-pocket medical expenditures for long-term care. How health affects household spending is an empirical question: on the one hand, health can affect a household’s budget through increased out-
Ooijen, R. van   +2 more
openaire   +2 more sources

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Does the leading pharmaceutical reform in China really solve the issue of overly expensive healthcare services? Evidence from an empirical study.

open access: yesPLoS ONE, 2018
BackgroundHealthcare system reform of Sanming city has become a leading healthcare reform model in China. It has developed a rigorous pharmaceutical reform consisted of the Zero Mark-up Drug Policy and the Centralized Procurement of Medicine Policy to ...
Yunzhen He   +6 more
doaj   +1 more source

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