Results 41 to 50 of about 893,794 (314)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Assessment of Availability, Affordability and Prescribing Patterns of Essential Medicines in Public Health Facilities in Tanga Region, Tanzani [PDF]

, 2011
To determine and assess the availability, affordability and prescribing pattern of essential medicines in public health of Tanzania. Setting: Availability, affordability, and rational use of medicines were assessed in primary health care centers in six
Francis, Michael K, Francis , Michael Kishiwa   +1 more
core  

Adoption of Electronic Medical Records in Healthcare Facilities in the Emirate of Dubai [PDF]

Healthcare Informatics Research
Objectives This paper aimed to assess the adoption of electronic medical records (EMRs) in healthcare facilities in Dubai, the largest city in the United Arab Emirates (UAE) and a location where extensive healthcare services are provided. It explored the
Mahera Abdulrahman, Osama El-Hassan, Mohammad Abdulqader Al Redha, Manal Almalki   +3 more
doaj   +1 more source

Poliovirus Immunity among Children Aged 6–11 and 36–48 Months in 14 Polio High-Risk Provinces of Afghanistan: A Health-Facility-Based Study

Vaccines, 2022
Afghanistan is one of two countries where wild poliovirus (WPV) type 1 remains endemic. We conducted a facility-based cross-sectional survey of antipoliovirus antibodies in children in 14 provinces of Afghanistan.
Sajid Bashir Soofi, Maureen Martinez, Noha H. Farag, William S. Hendley, Derek Ehrhardt, Imran Ahmed, Imtiaz Hussain, William Weldon, Ahmed M. Kassem   +8 more
doaj   +1 more source

Mapping Health Facilities

, 2021
“Mapping Health Facilities” discusses GRID3’s work with local stakeholders and data collectors to build capacity for the production and management of geospatial data on health facilities. This paper first discusses GRID3's approach to mapping health facility data. In the next section, it discusses GRID3's support of routine and non-routine immunisation
Center for International Earth Science Information Network, Flowminder Foundation, United Nations Population Fund, WorldPop, University of Southampton   +3 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Healthcare facility factors associated with health-seeking behavior among secondary school students in the Dodoma region: an analytical cross-sectional study

Frontiers in Public Health
BackgroundHealth-seeking behavior (HSB) is an important aspect of population health and is closely linked to a nation’s economic development. Its importance is reflected in the Sustainable Development Goal 3.
Karim Faragha Athumani, Joanes Faustine Mboineki   +1 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source