Results 91 to 100 of about 7,977,848 (398)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Health Financing Reforms for Moving towards Universal Health Coverage in the Western Pacific Region

open access: yesHealth systems and reform, 2019
This article provides an overview of health financing reforms across countries in the Western Pacific Region as progress is made toward universal health coverage (UHC).
A. Chu, Soonman Kwon, P. Cowley
semanticscholar   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Financing the U.S. Health System: Issues and Options for Change [PDF]

open access: yes, 2008
Explores key issues of health reform and options for financing health care -- redirecting funds to more effective uses, rolling back tax cuts, modifying tax exclusions for health benefits, an employer play-or-pay model, and a value-added ...
Jeanne M. Lambrew   +2 more
core  

Coverage, Timelines, and Determinants of Incomplete Immunization in Bangladesh

open access: yesTropical Medicine and Infectious Disease, 2018
Immunization has become one of the major contributors to public health globally as it prevents communicable disease, particularly in children. The objective of this study was to estimate the extent of timely immunization coverage and to investigate the ...
Nurnabi Sheikh   +6 more
doaj   +1 more source

Impact of macro-fiscal determinants on health financing: empirical evidence from low-and middle-income countries

open access: yesGlobal Health Research and Policy, 2019
BackgroundHealth financing is a major challenge in low-and middle-income counties (LMICs) for achieving Universal Health Coverage (UHC). Past studies have argued that the budgetary allocation on health financing depends on macro-fiscal policies of an ...
Deepak Kumar Behera, U. Dash
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Looking at the bigger picture: how the wider health financing context affects the implementation of the Tanzanian Community Health Funds

open access: yesHealth Policy and Planning, 2019
In Tanzania, the health financing system is extremely fragmented with strategies in place to supplement funds provided from the central level. One of these strategies is the Community Health Fund (CHF), a voluntary health insurance scheme for the ...
Sabine Renggli   +8 more
semanticscholar   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

Cross-Programmatic Efficiency: The System is Greater Than the Sum of Its Programs

open access: yesHealth Systems & Reform
Health programs play important roles in health systems, contributing to the development of best practices, guidelines, awareness, and advocacy for specific services, populations, or conditions.
Susan P. Sparkes   +2 more
doaj   +1 more source

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