Results 121 to 130 of about 684,204 (318)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Trinity Law Framework: Health Insurance Taxonomy

Encyclopedia
Despite seven decades of international commitment—from the 1948 Universal Declaration of Human Rights through SDG 3.8—universal health coverage remains stubbornly out of reach.
David Mark Dror
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Objective-Oriented Health Systems Reform

Health Systems & Reform
This paper emphasizes the importance of orienting health system reforms to address underlying system-level performance problems. Too often in practice, the objective-orientation that is stressed in health system frameworks gets lost in relation to ...
Joseph Kutzin, Susan P. Sparkes, Alexandra J. Earle, Agnes Gatome-Munyua, Nirmala Ravishankar   +4 more
doaj   +1 more source

Primary health care financing interventions: a systematic review and stakeholder-driven research agenda for the Asia-Pacific region [PDF]

, 2019
Blake Angell, Rebecca Dodd, Anna Palagyi, Thomas Gadsden, Ṣẹ̀yẹ Abímbọ́lá, Shankar Prinja, Stephen Jan, David Peiris   +7 more
openalex   +1 more source

New Ideas to Help the Aquino Administration Achieve its Health Agenda [PDF]

One of the inaugural commitments made by the Philippines` new administration is the provision of quality and affordable health care for each and every Filipino. To achieve this, a strategic health agenda is needed. This Policy Note offers a few new ideas
Lavado, Rouselle F.
core  

Health insurance reform in Vietnam: a review of recent developments and future challenges [PDF]

, 2017
Vietnam is undertaking health financing reform with a view to achieve universal coverage of health insurance within the coming years. To date, around half of the population is covered with some type of health insurance or prepayment.
Axelson, Henrik, Duc, Ha Anh, Ekman, Björn, Liem, Nguyen Thanh   +3 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source