Results 151 to 160 of about 685,929 (311)

Health financing: challenges and opportunities, coverage and cost [PDF]

This policy panel will present and debate proposals for the next steps in reforming the U.S. health care system. Which challenge deserves the highest priority – providing universal access; instituting better measures of quality and outcomes and better ...
James J. Mongan, M.D.
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The impact of COVID-19 on health financing in Kenya. [PDF]

PLOS Glob Public Health, 2023
Kairu A, Orangi S, Mbuthia B, Arwah B, Guleid F, Keru J, Vilcu I, Musuva A, Ravishankar N, Barasa E.   +9 more
europepmc   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Critical assessment of health financing indicators and expenditure in South Africa. [PDF]

Health SA
Mkhize NI.
europepmc   +1 more source

Lessons in change: adapting the World Bank’s ‘Flagship’ training course for the Pacific region [PDF]

Over the past three years, the Health Policy and Health Finance Hub has collaborated with the World Bank Institute (WBI) and the Harvard School of Public Health to develop a world-class training program to strengthen cohesively health systems and ...
Amanda Benson
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Rethinking global health financing: from philanthropy to public good. [PDF]

Glob Health Res Policy
Osborne A.
europepmc   +1 more source

Current Problems in the Financing of the Czech Public Health System [PDF]

The reform of the Czech public health system started in 1991. The main goals were the liquidation of the state's monopoly on health services, the creation of non-state health care that would include private facilities, and the introduction of multi ...
Vera Uldrichova
core