Results 71 to 80 of about 7,977,848 (398)

Analysis of the genotypic profile and its relationship with the clinical manifestations in people with cystic fibrosis: study from a rare disease registry

Orphanet Journal of Rare Diseases, 2022
Background Cystic fibrosis (CF) has a vast and heterogeneous mutational spectrum in Europe. This variability has also been described in Spain, and there are numerous studies linking CFTR variants with the symptoms of the disease.
Senay Rueda-Nieto, Pedro Mondejar-Lopez, María-Pilar Mira-Escolano, Ana Cutillas-Tolín, Luis Alberto Maceda-Roldán, Julián Jesús Arense-Gonzalo, Joaquín A. Palomar-Rodríguez   +6 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Strengthening Primary Health Care Through Community Health Workers: Investment Case And Financing Recommendations [PDF]

, 2015
A report released this week at the Third International Conference on Financing for Development found that there is a strong case for investing in Community Health Worker (CHW) programs as part of integrated health systems.
Addis Tamire Woldemariam, Akiko Maeda, Bernice Dahn, Chunling Lu, Drew Von Glahn, Henry Perry, Katy Vosburg   +6 more
core  

Assessment of socioeconomic and health vulnerability among urban slum dwellers in Bangladesh: a cross-sectional study

BMC Public Health
Background Bangladesh is rapidly urbanizing and approximately half of its urban population resides in deprived slums with limited access to basic needs. However, there is a dearth of information on vulnerability levels among slum dwellers.
Md Zahid Hasan, Md Golam Rabbani, Mohammad Wahid Ahmed, Gazi Golam Mehdi, Khadija Islam Tisha, Daniel D. Reidpath, Syed Manzoor Ahmed Hanifi, Shehrin Shaila Mahmood   +7 more
doaj   +1 more source

Exploring effectiveness of different health financing mechanisms in Nigeria; what needs to change and how can it happen?

BMC Health Services Research, 2019
Various attempts to examine health financing mechanisms in Nigeria highlight the fact that there is no single mechanism that fits all contexts and people.
O. Onwujekwe, N. Ezumah, C. Mbachu, F. Obi, H. Ichoku, B. Uzochukwu, Hong Wang   +6 more
semanticscholar   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Community-based financing of family planning in developing countries: A systematic review [PDF]

, 2016
In this systematic review, we gather evidence on community financing schemes and insurance programs for family planning in developing countries, and we assess the impact of these programs on primary outcomes related to contraceptive use.
Ali, Moazzam, Canning, David, Hu, Janice, Karra, Mahesh, Lissner, Craig   +4 more
core   +1 more source

The Effort to Rationalize Antibiotic Use in Indonesian Hospitals: Practice and Its Implication

Journal of Tropical Medicine, 2023
An effective strategy for combatting AMR in Indonesia is to make the use of antibiotics in hospitals more rational with the help of an Antimicrobial Resistance Control Program (AMR-CP).
Selma Siahaan, Rukmini Rukmini, Betty Roosihermiatie, Pramita Andarwati, Rini S. Handayani, Ingan U. Tarigan, Tita Rosita, Rustika Rustika, Yuslely Usman, Lusi Kristiana   +9 more
doaj   +1 more source

Vaccination Utilization and Subnational Inequities during the COVID-19 Pandemic: An Interrupted Time-Series Analysis of Administrative Data across 12 Low- and Middle-Income Countries

Vaccines, 2023
Background: During and after the SARS-CoV-2 (COVID-19) pandemic, many countries experienced declines in immunization that have not fully recovered to pre-pandemic levels.
George Mwinnyaa, Michael A. Peters, Gil Shapira, Rachel Neill, Husnia Sadat, Sylvain Yuma, Pierre Akilimali, Shahadat Hossain, Naod Wendrad, Wisdom K. Atiwoto, Anthony Adofo Ofosu, Jean Patrick Alfred, Helen Kiarie, Chea Sanford Wesseh, Chris Isokpunwu, Desmond Maada Kangbai, Abdifatah Ahmed Mohamed, Kadidja Sidibe, Salome’ Drouard, Pablo Amor Fernandez, Viviane Azais, Tawab Hashemi, Peter M. Hansen, Tashrik Ahmed   +23 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source