Results 161 to 170 of about 4,764,626 (316)

The Municipal Sustainable Development Health Index (MSDHI) to monitor the 2030 agenda in Brazil: a methodological proposal. [PDF]

Int J Equity Health
Fernandes LDMM, Marinho CV, Jardim LL, Rodrigues IB, Paes-Sousa R.   +4 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

RUL prediction method based on sequential health index evaluation with multidimensional coupled degradation data. [PDF]

PLoS One
Han F, Mo B.
europepmc   +1 more source

Health Utilities Index [PDF]

, 2020
openaire   +1 more source

System health Index methodology

The System Health Index (SHI) is a comprehensive methodology for assessing the stability, efficiency, and long-term resilience of any operational system. By aggregating thousands of real-time inputs—labor hours, production data, material costs, safety metrics, and budget forecasts—the SHI generates a single, clear measure of system health. This applied
openaire   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Tracking mangrove restoration using a biogeochemical soil health index and ecosystem service indicators. [PDF]

Sci Rep
Jimenez LCZ, Queiroz HM, Cherubin MR, Ruiz F, Ferreira TO.   +4 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A novel global health index framework for asset prognostics and health management in the oil and gas industry. [PDF]

Sci Rep
Alfahdi K, Gultekin H, Summad E.
europepmc   +1 more source