Results 161 to 170 of about 2,549,135 (316)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Valuation of the Child Health Utility Index 9D (CHU9D)

Objectives The aim of this study was to test the feasibility of estimating preference weights for all health states defined by the Child Health Utility 9D (CHU9D), a new generic measure of health related quality of life for children.
Stevens, K
core  

Development and Application of a Metabolic Health Index for the Chinese Population Aged 18 Years and Above. [PDF]

China CDC Wkly
Zhang Y, Fan X, Zhang T, Wang J, Wang W, Kan J, Luo R, Zhu Y, Zhao Z.   +8 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Relationship between Body Mass Index and Health-Related Quality of Life [PDF]

Study Objectives: This paper explores the relationship between body mass index (BMI) and health-related quality of life (HRQoL), measured using EQ-5D, for men and women within a national population sample.Methods: Data were taken from the 1996 Health ...
Susan Macran
core  

Assessing the Structural Validity and Measurement Invariance of the Whole Person Health Index. [PDF]

Glob Adv Integr Med Health
Cibelli Hibben K, Ryan VM, Nadreau R, Lamoreaux C, Forrest SE, Scanlon PJ, Earp M, Blumberg SJ.   +7 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Evolution of social inequalities in health in Quebec?

This paper, based on data from the National Population Health Surveys (NPHS) from 1994 to 2007, analyzes the evolution of social inequalities in health in Quebec since the mid-1990s using two health measures namely self-assessed health (SAH) and health ...
Batana, Yélé Maweki
core  

Analysis of Health and Activity Limitation Index (HALex), Its Distribution, andIts Distribution by Income in Japan, 1989 and 1998, [PDF]

It is a widely shared view in the population health field that the future of the analysis of population health lies in the assessment both of the length of life and health-adjusted quality of life, and the parallel examination of the average health and ...
Yukiko Asada, Yasushi Ohkusa
core  

Estimating the insulation health index of XLPE cables using machine learning. [PDF]

Sci Rep
Ansari A, Yousef Nia S, Afshari A, Mishra S.   +3 more
europepmc   +1 more source