Results 81 to 90 of about 2,159,135 (269)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Developing the Indonesian Student Health Index as an Instrument for Monitoring and Evaluating Student Health in Physical Education

Physical Education Theory and Methodology
Objectives. This study aimed to develop the Indonesian Student Health Index (ISHI), a valid, reliable, and practical instrument to comprehensively assess student health conditions in Indonesia, covering physical health, mental well-being, healthy ...
Widya Hary Cahyati, Adi S, Luh Nik Armini, Made Agus Dharmadi, Made Satya Nugraha Gautama, Risti Nurfadhila, Yudik Prasetyo, Rifky Riyandi Prastyawan, Mahenderan Appukutty   +8 more
doaj   +1 more source

Integral health index

, 2019
The main purpose of this study was to research basic clinical and hormonal, metabolic and psychological disturbances in children with obesity in various periods of the year. To estimate the effectiveness of occupational therapy and identify the features of different systems of the body depending on the periods of the year on the basis of the ...
Stepanenko, N. P., Yumasheva, Anna Leonidovna   +1 more
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Multi-Sensor Fusion and Deep Learning for Predictive Lubricant Health Assessment

Lubricants
Lubricating oil degradation directly impacts friction coefficient, wear rate, and lubrication regime transitions, making precise health quantification essential for predictive tribological maintenance.
Yongxu Chen, Jie Shen, Fanhao Zhou, Huaqing Li, Kun Yang, Ling Wang   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Dynamics of Scots pine health after the release of Thanasimus formicarius in bark beetle foci

Наукові праці Лісівничої академії наук України
In Eastern Polissia, a severe decline of Scots pine started in 2015. It was caused by drought and aggravated by outbreaks of Ips acuminatus (Gyllenhal, 1827) followed by Ips sexdentatus (Börner, 1776).
Valentyna Meshkova, Alla Vorobei, Eugene Vorobei, Denys Baturkin   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Autoencoder-Based Missing Data Imputation for Enhanced Power Transformer Health Index Assessment

Energies
Data sparsity, particularly the partial loss of diagnostic data caused by sensor failures, transmission errors, or missed inspections, frequently occurs in practical power transformer operations and significantly degrades the accuracy and reliability of ...
Seung-Yun Lee, Jeong-Sik Oh, Jae-Deok Park, Dong-Ho Lee, Tae-Sik Park   +4 more
doaj   +1 more source