Results 221 to 230 of about 582,179 (337)

A Nonviral Neo‐Nucleocapsid for Cell‐Specific RNA Delivery Developed by Pseudo‐Cyclic Peptide Grafting and Directed Evolution

open access: yesAngewandte Chemie, EarlyView.
Nonviral neo‐nucleocapsids developed from a repurposed bacterial protein cage, and macrocyclic peptide pharmacophores via protein‐protein ligation, bacteria‐based directed evolution, lasso‐grafting, and mammalian cell‐based directed evolution enabled cell specific RNA delivery.
Daiki Kanayama   +4 more
wiley   +2 more sources

Photochemical N‐dealkylation of Tertiary Amines Coupled With Photocharging of Poly(Heptazine Imides)

open access: yesAngewandte Chemie, EarlyView.
Protonated poly(heptazine imide) (H‐PHI) functions as an energy reservoir, thereby facilitating the endothermic dealkylation of triethylamine through a proton‐coupled two‐electron transfer (PC2ET) process. The extent of photocharging is quantitatively described by a molecular‐level descriptor, Ne:Nhept, providing a direct correlation between stored ...
Jingru Zhuang   +6 more
wiley   +2 more sources

Behavior Decoding Delineates Seizure Microfeatures and Associated Sudden Death Risks in Mouse Models of Epilepsy

open access: yesAnnals of Neurology, EarlyView.
Objective Behavior and motor manifestations are distinctive yet often overlooked features of epileptic seizures. Seizures can result in transient disruptions in motor control, often organized into specific behavioral sequences that can inform seizure types, onset zones, and outcomes.
Yuyan Shen   +8 more
wiley   +1 more source

Partnering with Students to Develop a Capstone for a Graduate Health Informatics Program. [PDF]

open access: yesAppl Clin Inform
Jezrawi R   +11 more
europepmc   +1 more source

Blockchain-Based Health Informatics Systems for Secure Patient Data Sharing and Interoperability

open access: diamond
Avni Garg   +6 more
openalex   +2 more sources

Speech Biomarkers From Smartphone Calls Track Progression in REM Sleep Behavior Disorder and Parkinson's Disease

open access: yesAnnals of Neurology, EarlyView.
Objective This 24‐month longitudinal study involving isolated rapid eye movement sleep behavior disorder (iRBD), early‐stage Parkinson's disease (PD), and matched healthy control subjects aimed to assess whether acoustic speech features from real‐world smartphone calls provide passive progressive biomarkers in synucleinopathies.
Michal Šimek   +11 more
wiley   +1 more source

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