Results 51 to 60 of about 30,225,962 (236)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Psychosocial determinants of health information seeking behavior

, 2023
Health information seeking behavior (HISB) concerns all the actions that individuals undertake to obtain information about their or others' health, with the goal to fulfill an information need.
Tanis, M., te Poel, F.
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Communication and information-seeking behavior of PhD students in physicists and astronomy [PDF]

, 2006
As a part of a wider doctoral research, this paper deals with the communication and information-seeking behavior of research (PhD) students in physics and astronomy.
Jamali, Hamid R.
core   +1 more source

Medical information seeking behavior of urban patients in Zhejiang Province, China: a cross-sectional study

BMC Public Health, 2022
Background Health information seeking behavior (HISB) is a prevalent research topic. However, little is known about sociodemographic factors of HISB in China.
Liyun Liu
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Predictors of Mental Health Literacy and Information Seeking Behavior Toward Mental Health Among University Students in Resource-Limited Settings

International Journal of General Medicine, 2022
Binyam Tariku Seboka,1 Samuel Hailegebreal,2 Misrak Negash,3 Tizalegn Tesfaye Mamo,1 Helen Ali Ewune,1 Girma Gilano,2 Delelegn Emwodew Yehualashet,1 Gelila Gizachew,3 Abel Desalegn Demeke,4 Aynadis Worku,5 Habtamu Endashaw,1 Chalachew Kassawe,3 Endris ...
Tariku Seboka B, Hailegebreal S, Negash M, Mamo TT, Ali Ewune H, Gilano G, Yehualashet DE, Gizachew G, Demeke AD, Worku A, Endashaw H, Kassawe C, Amede ES, Kassa R, Tesfa GA   +14 more
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Design and Developing of Health Information Behavior Questionnaire [PDF]

پیاورد سلامت
Background and Aim: The term “information behavior,” with an emphasis on health and hygiene, refers to purposeful actions taken to satisfy informational needs related to health.
Shahnaz Khademizadeh, Bahram Peymannia, Fatemeh Rafieinasab   +2 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source