Results 131 to 140 of about 10,653,637 (311)

Prioritising health information needs in Europe: a Policy Delphi survey [PDF]

open access: bronze, 2020
Stefanie Seeling   +9 more
openalex   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

A National Dialogue on Health Information Technology and Privacy [PDF]

open access: yes, 2009
Increasingly, government leaders recognize that solving the complex problems facing America today will require more than simply keeping citizens informed.
Alan P. Balutis   +4 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Healthy from the Start: Co‐Designing Sleep, Nutrition and Physical Activity Resources for Young Shiftworkers—Novel Implementation and Evaluation

open access: yesHealth Expectations
Introduction The increasing prevalence of shiftwork among young adults poses significant health risks, primarily due to its disruptive effects on sleep, nutrition and physical activity.
Alexandra E. Shriane   +11 more
doaj   +1 more source

Getting the Right Mix: Developing a primary - secondary health provider IT interface in the Waikato District Health Board [PDF]

open access: yes, 2007
The article presents a study on the electronic health record systems (EHR) developed by Waikato District Health Board (DHB) in New Zealand. The DHB develop EHR with the intention of integrating primary, secondary and tertiary provider information.
Gibb, Jenny L., Haar, Jarrod M.
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Readability and Suitability of Information Presented on a University Health Center Website.

open access: green, 2022
Alice Noblin   +6 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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