Results 171 to 180 of about 5,124,765 (263)

Harnessing digital health data for person-centred HIV prevention monitoring: a survey of national health information systems. [PDF]

J Int AIDS Soc
Dalal S, Mathers B, Stelzle D, Nyagah LM, Agbo F, Annang D, Bhavsar SP, Mbiriyawanda S, Mhlanga B, Molapo T, Moro L, Mudiope P, Ngwali L, Nyirenda MS, Sathane I, Adhikary R, Alonso Gonzalez M, Chan P, Gerritsen A, Izumi K, Kuchukhidze G, Mozalevskis A, Perrin G, Alaama AS, Tebogo M, Verster A, Low-Beer D.   +26 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Understanding Health Information Systems Utilization Across Public Health Centers in Indonesia: Cross-Sectional Study. [PDF]

JMIR Med Inform
Aisyah DN, Setiawan AH, Mayadewi CA, Lokopessy AF, Kozlakidis Z, Manikam L.   +5 more
europepmc   +1 more source

A Data-Driven Paradigm for a Resilient and Sustainable Integrated Health Information Systems for Health Care Applications. [PDF]

J Multidiscip Healthc, 2023
Epizitone A, Moyane SP, Agbehadji IE.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Blockchain in Health Information Systems: A Systematic Review. [PDF]

Int J Environ Res Public Health
Fonsêca ALA, Barbalho IMP, Fernandes F, Arrais Júnior E, Nagem DAP, Cardoso PH, Veras NVR, Farias FLO, Lindquist AR, Dos Santos JPQ, Morais AHF, Henriques J, Lucena M, Valentim RAM.   +13 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Estimating Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza Using Linked Public Health Information Systems, California, 2023-2024 Season. [PDF]

J Infect Dis
Zhu S, Quint J, León TM, Sun M, Li NJ, Yen C, Tenforde MW, Flannery B, Jain S, Schechter R, Hoover C, Murray EL.   +11 more
europepmc   +1 more source