Results 91 to 100 of about 20,721,570 (254)

Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes

BMC Medicine, 2017
Background Pregnant women with epilepsy frequently experience seizures related to pregnancy complications and are often prescribed anti-epileptic drugs (AEDs) to manage their symptoms.
Areti Angeliki Veroniki, Elise Cogo, Patricia Rios, Sharon E. Straus, Yaron Finkelstein, Ryan Kealey, Emily Reynen, Charlene Soobiah, Kednapa Thavorn, Brian Hutton, Brenda R. Hemmelgarn, Fatemeh Yazdi, Jennifer D’Souza, Heather MacDonald, Andrea C. Tricco   +14 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effect of lateral positioning on ventilation in patients with blunt thoracic injury during pressure support ventilation: the VICTORY study

Intensive Care Medicine Experimental
Background In patients with blunt thoracic injury requiring mechanical ventilation lateral positioning is routinely performed. Whether it modifies ventilation distribution and aeration is unclear.
Vorakamol Phoophiboon, Antenor Rodrigues, Matthew Ko, Luca S. Menga, Fernando Vieira, Mattia Docci, Kiana Sharifi, Annia Schreiber, Mayson L. A. Sousa, Alberto Goffi, Andrea Rigamonti, Laurent Brochard   +11 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Knowledge for better health – a conceptual framework and foundation for health research systems [PDF]

, 2003
Health research generates knowledge that can be utilized to improve health system performance and, ultimately, health and health equity. We propose a conceptual framework for health research systems (HRSs) that defines their boundaries, components, goals,
Pang, T, Sadana, Ritu, Sadana, R, Hanney, Steve, Hyder, Adnan A., Hyder, AA, Hanney, S, Bhutta, ZA, Pang, Tikki, Simon, J, Bhutta, Zulfiqar A., Simon, Jonathon   +11 more
core  

Health Knowledge Transfer [PDF]

Taṣvīr-i salāmat, 2014
Background and objectives : Knowledge transfer is a major issue in health promotion performance in the field of health education. Yet, there is still a big gap between the knowledge generated by research and knowledge being used in practice.
Zahra Golmohamadi
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

How can knowledge brokering be advanced in a country’s health system?

, 2013
49 p.There is a general lack of attention given to ‘what to do next’ to advance knowledge brokering in many European countries’ health systems. Four sets of interrelated issues can contribute to this problem within any given country’s health system: (1 ...
Catallo, Cristina, Lavis, John N, Permanand, Govin, BRIDGE Study Team, European Observatory on Health Systems and Policies, World Health Organization. Regional Office for Europe   +5 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source