Results 61 to 70 of about 20,721,570 (254)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Prioritising health research in KwaZulu-Natal: has the research conducted met the research needs?

Health Research Policy and Systems, 2020
Background The KwaZulu-Natal (KZN) Health Act of 2009 mandates the Provincial Health Research and Ethics Committee to develop health research priorities for the province.
G. Khumalo, R. Desai, X. Xaba, M. Moshabela, S. Essack, E. Lutge   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

HSE National Health Library & Knowledge Service Annual Report 2017

, 2017
This is the first annual report of the new National Health Library and Knowledge Service. It brings together a snapshot of the value that library staff, library infrastructure and centralised library services bring to the broader health service in 3 key
HSE National Health Library & Knowledge Service, Lawton, Aoife   +1 more
core  

Bangladesh: RH curriculum enhances vocational students\u27 knowledge and behavior [PDF]

, 2007
In 2004, the Population Council’s FRONTIERS Program and the Bangladesh Ministry of Youth and Sports collaborated on an intervention to introduce reproductive health education into government-run vocational-training courses. The training, offered to males
Frontiers in Reproductive Health
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Institutional Policy for Open Access to Scientific Publications

, 2008
The Centre’s compliance to open access principles The Norwegian Knowledge Centre for the Health Services (NOKC) encourages communication and exchange of the research results from our institutional activities, to increase their visibility and impact in ...
Norwegian Knowledge Centre for the Health Services
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Information and counselling on sexual health in cardiac and respiratory disease: description of community dwelling patients’ needs and reflections of health care professionals

International Journal for Equity in Health
Background Sexual health is an important aspect of overall well-being, encompassing physical, emotional, mental, and social dimensions. Despite its importance, many patients with chronic conditions, such as cardiac and respiratory diseases, experience ...
Leonie Klompstra, Tommy Persson, Elin Klingvall, Anna Skoglund, Frida Särén, Tiny Jaarsma   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source