Results 61 to 70 of about 2,724,206 (268)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Embedding rapid reviews in health policy and systems decision-making: Impacts and lessons learned from four low- and middle-income countries

Health Research Policy and Systems, 2023
Background Demand for rapid evidence-based syntheses to inform health policy and systems decision-making has increased worldwide, including in low- and middle-income countries (LMICs).
Reid C. Robson, Sonia M. Thomas, Étienne V. Langlois, Rhona Mijumbi, Ismael Kawooya, Jesmin Antony, Melissa Courvoisier, Krystle Amog, Robert Marten, Ivdity Chikovani, Devaki Nambiar, Rajani R. Ved, Soumyadeep Bhaumik, Nur Zahirah Balqis-Ali, Sondi Sararaks, Shakirah Md. Sharif, Rugare Abigail Kangwende, Ronald Munatsi, Sharon E. Straus, Andrea C. Tricco   +19 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Prioritising health research in KwaZulu-Natal: has the research conducted met the research needs?

Health Research Policy and Systems, 2020
Background The KwaZulu-Natal (KZN) Health Act of 2009 mandates the Provincial Health Research and Ethics Committee to develop health research priorities for the province.
G. Khumalo, R. Desai, X. Xaba, M. Moshabela, S. Essack, E. Lutge   +5 more
doaj   +1 more source

Knowledge translation in health sciences

Proceedings of the Association for Information Science and Technology, 2017
ABSTRACTKnowledge Translation (KT) is a term used by healthcare professionals and practitioners to represent a process of ensuring that what is learned in research is applied in the field. Knowledge Translation includes all stages in the research and research uptake life cycle.
Denise A. D. Bedford, Jeanine Turner, Theresa Norton, Liz Sabatiuk, Homira G. Nassery   +4 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Public health and the knowledge industry [PDF]

Revista de Saúde Pública, 2009
Knowledge plays an important role in health care. The production and diffusion of health-related knowledge are increasingly under the control of private commercial interests, which are characterized by conflicts of interests that result in abuses of power.
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Information and counselling on sexual health in cardiac and respiratory disease: description of community dwelling patients’ needs and reflections of health care professionals

International Journal for Equity in Health
Background Sexual health is an important aspect of overall well-being, encompassing physical, emotional, mental, and social dimensions. Despite its importance, many patients with chronic conditions, such as cardiac and respiratory diseases, experience ...
Leonie Klompstra, Tommy Persson, Elin Klingvall, Anna Skoglund, Frida Särén, Tiny Jaarsma   +5 more
doaj   +1 more source