Results 91 to 100 of about 8,992,126 (312)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Challenges and lessons from a primary care intervention in a Brazilian municipality

Revista de Saúde Pública, 2019
OBJECTIVE To address the implementation of the Lab for Innovation in Chronic Conditions in Santo Antonio do Monte, indicating the main challenges and lessons of a new chronic condition model. METHODS This is an observational study based on two sources
Mônica V Andrade, Kenya Noronha, Clareci S Cardoso, Claudia D L Oliveira, Júlia A Calazans, Michelle N Souza   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Quantificação do indicador de Nelson de Moraes (curva de mortalidade proporcional)

Revista de Saúde Pública
Propõe-se um critério para quantificação do indicador de Nelson de Moraes (curva de mortalidade proporcional) procurando eliminar as desvantagens do indicador não ter tradução numérica.
José da Silva Guedes, Marilda Lauretti da Silva Guedes   +1 more
doaj  

Clinical guidelines as plans: An ontological theory [PDF]

, 2006
Clinical guidelines are special types of plans realized by collective agents. We provide an ontological theory of such plans that is designed to support the construction of a framework in which guideline-based information systems can be employed in the ...
Gangemi, Aldo, Kumar, Anand, Pisanelli, Domenica, Smith, Barry, Stefanelli, Mario   +4 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

New Approaches and Biomarker Candidates for the Early Detection of Ovarian Cancer

Frontiers in Bioengineering and Biotechnology, 2022
K. R. Hossain, J. D. Escobar Bermeo, J. D. Escobar Bermeo, K. Warton, S. M. Valenzuela, S. M. Valenzuela   +5 more
doaj   +1 more source

A neighborhood-level potential health impact scoring tool to support local-level health impact assessments

Cities & Health, 2019
Health Impact Assessments (HIAs) have quickly become a widely utilized tool for integrating health and health-related evidence and data into decision making processes across a range of projects and polices. Integrating and utilizing the wide range of available data can be daunting.
John D, Prochaska, Robert N, Buschmann, Daniel C, Jupiter   +2 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source