Results 121 to 130 of about 8,992,126 (312)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Self-assessed health, reference levels, and mortality [PDF]

open access: yes
The paper studies the relationship between self-assessed health and subsequent mortality in the German Socio-Economic Panel. Specifically, I examine whether socio-economic characteristics of respondents have an effect on mortality, conditional on self ...
Hendrik Jürges
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A mentőállomások településen belüli elhelyezkedésének jellemzői Magyarországon az Országos Mentőszolgálat megalakulása után = Spatial distribution of ambulance stations within settlements in Hungary after the establishment of the National Ambulance Service

open access: yesModern Geográfia
The study examines the spatial characteristics of ambulance stations in Hungary. After 1948, the location of these stations changed mainly during the 1950s and 1960s, particularly in settlements with a population of over 10,000.
Ecsegi, Dániel, Kozma, Gábor
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Pavement performance levels causing human health risks

open access: yesGrađevinar, 2018
This study investigates performance thresholds of hot mix asphalt pavements in terms of health risks from vibrations affecting drivers of passenger cars on urban roads.
Ufuk Kırbaş, Mustafa Karaşahin
doaj   +1 more source

Charting a New Direction: Exploring the Future of Justice Mapping [PDF]

open access: yes, 2008
Outlines how new mapping technologies help analyze the spatial dynamics of crime, prisoner reentry, poverty, poor health, low education levels, and homelessness, and the impact of criminal justice policies on communities.
Brian Elderbroom   +2 more
core  

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