Results 171 to 180 of about 1,408,925 (327)

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

The role of MedDRA in global pharmacovigilance and public health during COVID-19: pandemic preparedness and response. [PDF]

Front Drug Saf Regul
O'Hare B, Ibrahim H, Revelle P.
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Implementing ICOPE in New Mexico: A process-oriented approach to promoting healthy aging in older adults. [PDF]

JAR Life
Gm RS, Al S, Ey J, Ia P, Mb GE, Kd W, L V, Ak D, Ck B, S A, Jw H, Ds S, Dl W.   +12 more
europepmc   +1 more source

Impact of health maintenance organizations and fee-for-service on health care utilization among people with systemic lupus erythematosus.

Arthritis & Rheumatism, 2007
E. Yelin, L. Trupin, P. Katz, L. Criswell, J. Yazdany, J. Gillis, Peter Panopalis   +6 more
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A systemic methodology for risk management in healthcare sector [PDF]

, 2011
Anna Corinna Cagliano, Apkon, Armitage, Barach, Bartlett, Baysari, Baysari, Bridges, Brown, Burgmeier, Carlo Rafele, Cohen, Cosby, Damelio, Davis, Embrey, Embrey, Garthwaite, Graham, Gray, Harms-Ringdahl, Harvard Business School, Hillson, Hillson, Hollnagel, Hollnagel, Janssen, Johansson, Körvers, Leape, Liker, Liker, Linch, Lucas, Lyons, Lyons, McDonald, McNally, Norman, Ohno, Ookalkar, O’Hagan, Paz Barroso, Project Management Institute, Project Management Institute, Reason, Reason, Ross Baker, Roth, Sabrina Grimaldi, Saizy-Callaert, Sale, Stalhandske, Thomas, Tonneau, Vincent, Vincent, Vincent, Vissers, Wiegmann, Wieman, Wilson, Zidel   +62 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Implementing the ICOPE program amongst community-dwelling older adults in Singapore: a multistage implementation study protocol. [PDF]

Front Public Health
Wang Q, Tan LF, Tan WM, Merchant RA, Sevdalis N.   +4 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source