Results 51 to 60 of about 2,598,681 (268)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Evaluation of Behavioral Aspects after Intradermal and Intramuscular Vaccine Application in Suckling Piglets

Agriculture, 2020
The aim of this study was to analyse the behavioral aspects of suckling piglets after an intradermal vaccination method in comparison to an intramuscular vaccination applied on the seventh day of life.
Manuel Göller, Nicole Kemper, Michaela Fels   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Machine learning in coronary heart disease prediction: Structural equation modelling approach

Cogent Engineering, 2020
This research is an application of machine learning in medical sciences. The purpose of this research was to use machine learning through the simulated data to study the association of age, body mass index, cigarettes smoked per day, alcohol consumed per
Lewlyn L. R. Rodrigues, Dasharathraj K Shetty, Nithesh Naik, Chetana Balakrishna Maddodi, Anuradha Rao, Ajith Kumar Shetty, Rama Bhat, B. M. Zeeshan Hameed   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

An Overview of Artificial Intelligence-Based Techniques for PEMFC System Diagnosis

IEEE Access
Proton Exchange Membrane Fuel Cell (PEMFC) systems represent a crucial clean energy component, offering a sustainable alternative to traditional power sources.
Priynka Sharma, Maurizio Cirrincione, Ali Mohammadi, Giansalvo Cirrincione, Rahul R. Kumar   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Health Project Prioritization in Meta, Colombia, Using Anp-Dematel

Applied Sciences
The prioritization of healthcare projects in Colombia’s Meta Department was conducted using an integrated decision-making model that combines the Analytic Network Process and the Decision-Making Trial and Evaluation Laboratory.
Astrid León-Camargo, Seydyss Garay-Rodríguez   +1 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Health Management of Working Pregnant Nurses: A grounded theory study

Nursing Open
Aim To explore the recognition of pregnant nurses on how they managed their health conditions to examine safe working strategies. Design A qualitative study with a grounded theory approach. Methods Twenty‐one nurses engaged in work during their pregnancy
Marie Hino, Risa Takashima, Rika Yano
doaj   +1 more source