Results 51 to 60 of about 2,728,520 (269)

Mapping Healthcare Needs: A Systematic Review of Population Stratification Tools

Medical Sciences
Background and Aim: In 2021, healthcare expenditure in Italy represented 7.3% of the national gross domestic product, with approximately 80% attributed to the management of chronic diseases—an increasing burden associated with population aging ...
Giovanni Genovese, Caterina Elisabetta Rizzo, Antonio Nirta, Linda Bartucciotto, Roberto Venuto, Francesco Fedele, Raffaele Squeri, Cristina Genovese   +7 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Hospitalizations and deaths from respiratory diseases in the state of Minas Gerais: analysis of time series between 2016-2022 of public hospital records (SIH/SUS)

Revista Médica de Minas Gerais
OBJECTIVE: To evaluate the temporal patterns of hospitalizations and deaths from respiratory diseases (RD) in Minas Gerais from 2016 to 2022. METHODS: We conducted a data survey from the SIH-SUS/ DATASUS database, focusing on hospitalizations and deaths
Ryan Rodrigo Oliveira de Paula, Thelma Safadi, Luiz Otávio de Oliveira Pala, Luciano José Pereira   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Role of Curcumin in Disease Prevention and Treatment

Advanced Biomedical Research, 2018
Treatment based on traditional medicine is very popular in developing world due to inexpensive properties. Nowadays, several types of preparations based on medicinal plants at different dose have been extensively recognized in the diseases prevention and
Arshad Husain Rahmani, Mohammed A Alsahli, Salah M Aly, Masood A Khan, Yousef H Aldebasi   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Self-management and role of nurses of diabetic patients: a critical narrative literature review during COVID-19 pandemic

Frontiers in Medicine
BackgroundDuring COVID-19 and the postepidemic phase, the concept of a frontline emergency response team was gradually expanded [based on a previous clinical trial, https://clinicaltrials.gov/, identifier (ChiCTR2500103976)].
Zhixiong Zhuang, Yan Bo
doaj   +1 more source