Results 91 to 100 of about 230,350 (293)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Revista de Ciencias Médicas de Pinar del Río, 2009 RESUMEN Con el objetivo de identificar las tendencias existentes acerca de cómo se dirige el PDE de los estudiantes de la Carrera de Medicina de todos los años, a nivel del Consultorio Médico en su componente investigativo laboral, se realizó el presente
Lázara Mayra Díaz Álvarez +4 more
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Study of Industrial Relations: Labor Union, Work Agreement and Bipartit [PDF]
, 2019 The demonstration on May 1 was a sign of industrial relations problems. Therefore, all involved parties (Company, Labor Union, Bipartit and Governance) must enforce the rules of employment agreements as stipulated in the labor law. Explicitly, this study
Haryono, M. (Mr)
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Woodbury, Town of and Woodbury Police Benevolent Association (Dispatchers) [PDF]
, 2008 In the Matter of TOWN OF WOODBURY, Orange County and WOODBURY POLICE BENEVOLENT ASSOCIATION (Dispatchers). FINDINGS OF FACT and RECOMMENDATIONS FOR RESOLUTION. Peter A.
Korn, Peter A.
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Skills Training Works: Examining the Evidence [PDF]
, 2002 In spite of public consensus that education and training lead to economic advancement, recent federal policies have made it harder for low-income Americans to get the education and training they need to succeed in today's economy.
Andy Van Kleunen +3 more
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Revista de Ciencias Médicas de Pinar del Río, 2007 Uno de los retos que se ha planteado nuestro país en los últimos años lo constituye la calidad de la formación y superación de Recursos Humanos. Este proceso ha estado vinculado directamente a los cambios políticos, económicos y sociales, por lo que nos ...
Maritza Peinado Moreno +3 more
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