Results 101 to 110 of about 706,569 (317)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Development of the short form of the Korean health literacy scale for the elderly [PDF]

open access: yes, 2013
We developed and examined a shortened form of the Korean Health Literacy Scale (KHLS) with a sample of 543 elderly in South Korea. Rasch analysis of the KHLS was conducted to examine the unidimensionality of the scale, along with a confirmatory factor ...
이태화
core   +1 more source

An analytical study of the interior design of nursing homes for the elderly and its impact on enhancing their mental health

open access: yesMaǧallaẗ Al-Turāṯ wa Al-Taṣmīm
Many older people lose their ability to live independently, due to limited movement, chronic pain, weakness, or other psychological and physical problems, all of these factors can lead to loneliness and psychological distress to them, so they need a form
Dr. Mona Sayed Othman Badr Othman
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Sociodemographic and Health Profile of the Elderly in the city of João Pessoa – PB [PDF]

open access: yesRevista Brasileira em Promoção da Saúde, 2012
Objective: To explore the sociodemographic profile and physical health of elderly enrolled in Family Health Units (USF) in the city of João Pessoa – PB, Brazil, and the factors associated with self-reported diagnoses in this population.
Laryssa Dantas Dias   +4 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Public Policy and Health Care Choices of the Elderly: Evidence from the Medicare Buy-In Program [PDF]

open access: yes
This study provides evidence on the economic decisions of senior citizens with respect to the largest means-tested program in the United States: the Medicaid program. Virtually all senior citizens have health insurance coverage through Medicare, but poor
A. S. Yelowitz
core  

Analysis of the Characteristics and Health Status of the Residents of a Large Nursing Home in Taiwan [PDF]

open access: yes, 2009
[[abstract]]Objective: The objective of this study is to gain an understanding of the determining factors of taking long-term care (LTC) residency and the characteristics and health status of the residents of a selected LTC center in Taiwan.
ALAN C. TSAI;PEI-YU KU
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

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