Results 71 to 80 of about 706,569 (317)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Frailty In Older Adults Attending An Outpatient Geriatric Clinic As Measured By The Visual Scale Of Frailty [PDF]

Geriatrics, Gerontology and Aging
BACKGROUND: Existing instruments for the diagnosis of frailty are limited by their focus on mobility evaluation, failure to incorporate comorbidities, and dichotomous classification of patients as frail or non-frail, which hinders adequate identification
Marco Túlio Gualberto Cintra, Felipe Ferreira Guimarães, Cislene Teixeira de Souza, Fernanda Silva Trindade Luz, Érica Dias Murta, Maria Aparecida Camargos Bicalho, Edgar Nunes de Moraes   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Health and Labor Force Participation of the Elderly in Taiwan [PDF]

Estimates are reported of the consequences of health on participation in the labor force of elderly men and women in Taiwan from 1989 to 1996. Three survey indicators of individual health are examined, and two are estimated by instrumental variables (IV),
Cem Mete, T. Paul Schultz
core  

O olhar dos conselheiros de saúde da Região Metropolitana de São Paulo sobre serviços de saúde para idosos: 'Quem cuidará de nós em 2030?'

Saúde em Debate
O estudo foi desenvolvido por meio de um recorte da pesquisa: 'Quem cuidará de nós em 2030?'. Sob a ótica dos conselheiros de saúde buscou-se compreender a percepção sobre os serviços oferecidos hoje e os que seriam necessários em 2030 para os idosos. Ao
Ana Paula Leal Loureiro da Silva, Otávio Toledo Nóbrega, Beltrina Côrte   +2 more
doaj   +1 more source

Long-stay institutions for the elderly: physical-structural and organizational aspects

Escola Anna Nery, 2017
Objective: To characterize long-stay institutions for the elderly in respect to physical-structural and organizational aspects. Method: This descriptive, cross-sectional, quantitative research was carried out in four long-stay institutions for the ...
Manuela Bastos Alves, Maria do Rosário de Menezes, Ridalva Dias Martins Felzemburg, Valdenir Almeida da Silva, Juliana Bezerra do Amaral   +4 more
doaj   +1 more source

Patients’ experiences with fluctuations in persistent physical symptoms: a qualitative study

BMJ Open, 2020
Objectives To explore patients’ experiences with fluctuations in persistent physical symptoms (PPS) and to understand which factors—from their viewpoint—play a role in these fluctuations.Design Qualitative study using semistructured interviews and ...
Johannes C van der Wouden, Hieke Barends, Ella Walstock, Femke Botman, Anja de Kruif, Nikki Claassen, Tim olde Hartman, Joost Dekker, Henriette van der Horst   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Brazilian Consensus On Frailty In Older People: Concepts, Epidemiology And Evaluation Instruments [PDF]

Geriatrics, Gerontology and Aging
The aim of the present study was to describe the conceptual and operational definitions of the frailty syndrome recommended by the Brazilian Consensus on Frailty in Older People.
Roberto Alves Lourenço, Virgílio Garcia Moreira, Renato Gorga Bandeira de Mello, Itamar de Souza Santos, Sumika Mori Lin, Ana Lúcia Fiebrantz Pinto, Lygia Paccini Lustosa, Yeda Aparecida de Oliveira Duarte, Juliana Alcântara Ribeiro, Clarice Câmara Correia, Henrique Novaes Mansur, Euler Ribeiro, Roberta Rigo Dalla Corte, Eduardo Ferriolli, Carlos André Uehara, Ana Maeda, Tamara Petroni, Terezinha Silva Lima, Sergio Falcão Durão, Ivan Aprahamian, Carla Maria Avesani, Wilson Jacob Filho   +21 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source