This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu+12 more
wiley +1 more source
Emergency Medical Service Personnel Satisfaction Regarding Ambulance Service Facilities and Welfare
Introduction: Personnel job satisfaction, facilities and welfare are among the most important factors affecting quality of service. To date, no study has been done in the field of Emergency medical service (EMS) personnel satisfaction regarding ...
Ali Asghar Jesmi+4 more
doaj
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci+6 more
wiley +1 more source
Oral health planning in João Pessoa municipality , Paraíba State: Dental surgeons as protagonists of Basic Care = Planejamento em saúde bucal no município de João Pessoa, Estado da Paraíba: o cirurgião-dentista enquanto protagonista da atenção básica [PDF]
The aim was to identify the perception of Oral Health Planning (OHP) of basic care (BC) dental surgeons (DSs) in João Pessoa, Para ba State, Brazil. Seventeen BC DSs from João Pessoa were interviewed.
Yuri Wanderley Cavalcanti+4 more
doaj
Stakeholders' Participation in Planning and Priority Setting in the Context of a Decentralised Health Care system: the case of prevention of mother to child Transmission of HIV Programme in Tanzania. [PDF]
In Tanzania, decentralisation processes and reforms in the health sector aimed at improving planning and accountability in the sector. As a result, districts were given authority to undertake local planning and set priorities as well as allocate ...
A Blystad+40 more
core +3 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte+10 more
wiley +1 more source
Editorial: Public Health Data Challenges of the COVID-19 pandemic: A Sisyphean task!
Carla Sofia Farinha+9 more
doaj +1 more source
Animal Health Planning and Animal Health Plans - Concepts, principles and practicalities [PDF]
In the United Kingdom it is mandatory for organic livestock farms to have an animal health plan as a document providing evidence of active management of disease and building positive health (Anon 2006).
Atkinson, Chris, Neale, Madeleine
core
Low level of attention to health inequalities in prevention planning activities of the Italian Regions [PDF]
Background: Health promotion and prevention activities should tackle health inequalities to reduce disparities in health among disadvantaged populations.
D'ANDREA, ELVIRA+7 more
core +2 more sources
Comprehensive cancer centre (CCCs) and CCCs of Excellence (CCCoE) integration in healthcare. Through outreach to surrounding community hospitals, CCCs enable wider access to top‐clinical cancer treatments and care, thereby facilitating the swift enrolment of patients into data‐rich clinical trials (PI‐initiated trials testing new concepts, drug ...
Anton Berns+4 more
wiley +1 more source